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A Novel Stimuli-Responsive Magnetic Hydrogel Based on Nature-Inspired Tragacanth Gum for Chemo/Hyperthermia Treatment of Cancerous Cells Publisher



Khani A1 ; Eskandani M2 ; Derakhshankhah H3 ; Soleimani K4 ; Nakhjavani SA5 ; Massoumi B6 ; Jahanbanesfahlan R7 ; Moloudi K8 ; Jaymand M4
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Authors Affiliations
  1. 1. Radiation Sciences Department, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Biomedicine institute, Tabriz, Iran
  3. 3. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Chemistry, Payame Noor University, Tehran, Iran
  7. 7. Department of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Department of Radiology and Nuclear Medicine, Alley School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Journal of Polymer Research Published:2022


Abstract

An efficient and facile strategy for the fabrication of a bioinspired drug delivery system (DDS) was designed and developed successfully based on tragacanth gum (TG) owing to its wide range of biological and pharmacological activities (e.g., anti-tumor). For this objective, the reduced TG (TG-OH) was tosylated (TG-OTs), and then 2-ethyl-2-oxazoline (EtOx) monomer was grafted onto purified TG through a cationic ring-opening polymerization (CROP) technique. The polymerization was terminated and simultaneously crosslinked by the addition of amine-modified Fe3O4 nanoparticles and cystamine (Cys) moiety to afford a TG-g-PEtOx/Fe3O4 as a pH- and reduction-sensitive magnetic hydrogel (MH). The fabricated MH exhibited excellent doxorubicin hydrochloride (Dox) encapsulation efficiency (83.1 ± 3.1) owing to its porous micro-structure and robust physical interactions between the drug molecule and polymeric network. In vitro drug release studies results confirmed the pH- and reduction-responsiveness of the developed MH/Dox system. The anticancer performance study by MTT-assay revealed that the developed MH/Dox has excellent potential for “smart” chemo/hyperthermia therapy of cancerous cells. © 2022, The Polymer Society, Taipei.
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