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Multi-Stimuli-Responsive Magnetic Hydrogel Based on Tragacanth Gum As a De Novo Nanosystem for Targeted Chemo/Hyperthermia Treatment of Cancer Publisher



Jahanbanesfahlan R1 ; Soleimani K2 ; Derakhshankhah H3 ; Haghshenas B4 ; Rezaei A2 ; Massoumi B5 ; Farnudiyanhabibi A6, 7 ; Samadian H2 ; Jaymand M2
Authors
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Authors Affiliations
  1. 1. Department of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Regenerative Medicine Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Department of Chemistry, Payame Noor University, Tehran, Iran
  6. 6. Department of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Materials Research Published:2021


Abstract

A novel magnetic pH- and redox-responsive drug delivery system (DDS) based on natural Tragacanth gum (TG) was developed for targeted chemo/hyperthermia treatment of cancer. Firstly, acrylic acid (AA) monomer was grafted onto a maleic anhydride-functionalized TG macromonomer (MATGM) through a free radical copolymerization. Magnetic nanoparticles (MNPs) were synthesized through chemical co-precipitation, and subsequently were modified using (3-aminopropyl)triethoxysilane coupling agent. The magnetic stimuli-responsive hydrogel for targeted cancer therapy was synthesized by the incorporation of modified-MNPs and folic acid (FA), and simultaneous crosslinking of TG-g-PAA copolymer using cystamine (Cys) moiety. Doxorubicin hydrochloride (Dox) was loaded into the fabricated magnetic hydrogel (MH), and its release was studied under pH- and redox-triggered condition. The anti-cancer activity of the Dox-loaded DDS was examined against MCF7 cells through MTT assay by both chemotherapy and chemo/hyperthermia therapy approaches. It was revealed that the developed DDS has higher anti-cancer activity (~ 24%) owing to its “smart” and slow drug release behavior as well as synergic effect of hyperthermia therapy. Graphic abstract: A novel magnetite pH- and redox-responsive drug delivery system (DDS) based on natural Tragacanth gum (TG) was design and developed for targeted chemo/hyperthermia therapy of solid tumors. [Figure not available: see fulltext.]. © 2021, The Author(s), under exclusive licence to The Materials Research Society.
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