Confirmation of Fifth Candida Auris Clade by Whole Genome Sequencing

Confirmation of Fifth Candida Auris Clade by Whole Genome Sequencing Publisher Pubmed

Spruijtenburg B^{1, 2} ; Badali H³ ; Abastabar M⁴ ; Mirhendi H⁵ ; Khodavaisy S⁶ ; Sharifisooraki J⁷ ; Taghizadeh Armaki M⁸ ; De Groot T^{1, 2} ; Meis JF^{1, 2, 9}

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1. Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, Netherlands
2. Centre of Expertise in Mycology, Radboud University Medical Center, Canisius Wilhelmina Hospital, Nijmegen, Netherlands
3. Department of Molecular Microbiology & Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, United States
4. Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
5. Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
6. Faculty of Public Health, Department of Medical Parasitology and Mycology, Tehran University of Medical Sciences, Tehran, Iran
7. Health Reproductive Research Center, Sari Branch, Islamic Azad University, Sari, Iran
8. Department of Medical Mycology and Parasitology, School of Medicine, Babol University of Medical Sciences, Babol, Iran
9. Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands

Source: Emerging Microbes and Infections Published:2022

Abstract

Candida auris has emerged globally as a multidrug-resistant pathogen causing outbreaks in health care facilities. Whole genome sequencing (WGS) analysis has identified four major clades, while earlier WGS data from a single Iranian isolate suggested the existence of a potential fifth clade. Here, we confirm the existence of this fifth clade by providing WGS data of another four Iranian isolates. These clade V isolates differed less than 100 single-nucleotide polymorphisms (SNPs) between each other, while they were separated from the other clades by more than 200,000 SNPs. Two of these isolates were resistant to fluconazole and were found to harbour mutations in the TAC1b and ERG11 genes. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.

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kazem Ahmadikia (3)

Sadegh Khodavaisy (3)

Style	Citing Format
MLA	Spruijtenburg B, et al.. "Confirmation of Fifth Candida Auris Clade by Whole Genome Sequencing." Emerging Microbes and Infections, vol. 11, no. 1, 2022, pp. 2405-2411.
APA	Spruijtenburg B, Badali H, Abastabar M, Mirhendi H, Khodavaisy S, Sharifisooraki J, Taghizadeh Armaki M, De Groot T, Meis JF (2022). Confirmation of Fifth Candida Auris Clade by Whole Genome Sequencing. Emerging Microbes and Infections, 11(1), 2405-2411.
Chicago	Spruijtenburg B, Badali H, Abastabar M, Mirhendi H, Khodavaisy S, Sharifisooraki J, Taghizadeh Armaki M, De Groot T, Meis JF. "Confirmation of Fifth Candida Auris Clade by Whole Genome Sequencing." Emerging Microbes and Infections 11, no. 1 (2022): 2405-2411.
Harvard	Spruijtenburg B et al. (2022) 'Confirmation of Fifth Candida Auris Clade by Whole Genome Sequencing', Emerging Microbes and Infections, 11(1), pp. 2405-2411.
Vancouver	Spruijtenburg B, Badali H, Abastabar M, Mirhendi H, Khodavaisy S, Sharifisooraki J, et al.. Confirmation of Fifth Candida Auris Clade by Whole Genome Sequencing. Emerging Microbes and Infections. 2022;11(1):2405-2411.
BibTex	@article{ author = {Spruijtenburg B and Badali H and Abastabar M and Mirhendi H and Khodavaisy S and Sharifisooraki J and Taghizadeh Armaki M and De Groot T and Meis JF}, title = {Confirmation of Fifth Candida Auris Clade by Whole Genome Sequencing}, journal = {Emerging Microbes and Infections}, volume = {11}, number = {1}, pages = {2405-2411}, year = {2022} }
RIS	TY - JOUR AU - Spruijtenburg B AU - Badali H AU - Abastabar M AU - Mirhendi H AU - Khodavaisy S AU - Sharifisooraki J AU - Taghizadeh Armaki M AU - De Groot T AU - Meis JF TI - Confirmation of Fifth Candida Auris Clade by Whole Genome Sequencing JO - Emerging Microbes and Infections VL - 11 IS - 1 SP - 2405 EP - 2411 PY - 2022 ER -

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