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Genetic Diversity and Antifungal Susceptibility of Candida Albicans Isolated From Iranian Patients Publisher Pubmed



Sharifynia S1, 2 ; Rezaie S2 ; Mohamadnia A3 ; Mortezaee V4 ; Hadian A2 ; Seyedmousavi S4, 5, 6, 7
Authors
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Authors Affiliations
  1. 1. Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Division of Molecular Biology, Department of Medical Mycology and Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Virology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Invasive Fungi Research Center, Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  5. 5. Department of Microbiology and Immunology, Center of Excellence for Infection Biology and Antimicrobial Pharmacology, Tehran, Iran
  6. 6. Department of Medical Microbiology, Radboud University Medical Center, Center of Expertise in Mycology RadboudUMC/CWZ, Nijmegen, Netherlands
  7. 7. Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States

Source: Medical Mycology Published:2019


Abstract

A total of 105 independent Candida albicans strains isolated from patients in Iran were investigated. According to CLSI documents M27-A3 and M27-S4, the 24 h geometric mean MICs of caspofungin, itraconazole, and fluconazole were 0.27, 3.19, and 11.91 μg/ml, respectively. Microsatellites analysis of CEF3, CAIII, LOC4 Loci identified 93 different allelic genotypes clustered apart into six different clades. Antifungal susceptibility was not linked with the source of isolation and the corresponding genotype of C. albicans strains. © The Author(s) 2018. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved.
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