The Inhibitory Effect of Disulfiram Encapsulated Plga Nps on Tumor Growth: Different Administration Routes

The Inhibitory Effect of Disulfiram Encapsulated Plga Nps on Tumor Growth: Different Administration Routes Publisher Pubmed

Fasehee H¹ ; Zarrinrad G² ; Tavangar SM³ ; Ghaffari SH² ; Faghihi S¹

Show Affiliations

1. Tissue Engineering and Biomaterials Research Center, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, 14965/161, Iran
2. Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Science, Tehran, Iran
3. Department of Pathology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Materials Science and Engineering C Published:2016

Abstract

The strong anticancer activity of disulfiram is hindered by its rapid degradation in blood system. A novel folate-receptor-targeted poly (lactide-co-glycolide) (PLGA)-polyethylene glycol (PEG) nanoparticle (NP) is developed for encapsulation and delivery of disulfiram into breast cancer tumor using passive (EPR effect) and active (folate receptor) targeting. The anticancer activity of disulfiram and its effect on caspase-3 activity and cell cycle are studied. The administration of encapsulated PLGA NPs using intra-peritoneal, intravenous and intra-tumor routes is investigated using animal model. Disulfiram shows strong cytotoxicity against MCF7 cell line. The activity of caspase-3 inhibited with disulfiram via dose dependent manner while the drug causes cell cycle arrest in G0/G1 and S phase time-dependently. The encapsulated disulfiram shows higher activity in apoptosis induction as compared to free drug. In nontoxic dose of encapsulated disulfiram, the highest and lowest efficacy of NPs in tumor growth inhibition is observed for intravenous injection and intraperitoneal injection. It is suggested that administration of disulfiram by targeted PLGA nanoparticles using intravenous injection would present an alternative therapeutic approach for solid tumor treatment. © 2016 Elsevier B.V. All rights reserved.

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Seyed Hamidollah Ghaffari (4)

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Style	Citing Format
MLA	Fasehee H, et al.. "The Inhibitory Effect of Disulfiram Encapsulated Plga Nps on Tumor Growth: Different Administration Routes." Materials Science and Engineering C, vol. 63, no. , 2016, pp. 587-595.
APA	Fasehee H, Zarrinrad G, Tavangar SM, Ghaffari SH, Faghihi S (2016). The Inhibitory Effect of Disulfiram Encapsulated Plga Nps on Tumor Growth: Different Administration Routes. Materials Science and Engineering C, 63(), 587-595.
Chicago	Fasehee H, Zarrinrad G, Tavangar SM, Ghaffari SH, Faghihi S. "The Inhibitory Effect of Disulfiram Encapsulated Plga Nps on Tumor Growth: Different Administration Routes." Materials Science and Engineering C 63, no. (2016): 587-595.
Harvard	Fasehee H et al. (2016) 'The Inhibitory Effect of Disulfiram Encapsulated Plga Nps on Tumor Growth: Different Administration Routes', Materials Science and Engineering C, 63(), pp. 587-595.
Vancouver	Fasehee H, Zarrinrad G, Tavangar SM, Ghaffari SH, Faghihi S. The Inhibitory Effect of Disulfiram Encapsulated Plga Nps on Tumor Growth: Different Administration Routes. Materials Science and Engineering C. 2016;63():587-595.
BibTex	@article{ author = {Fasehee H and Zarrinrad G and Tavangar SM and Ghaffari SH and Faghihi S}, title = {The Inhibitory Effect of Disulfiram Encapsulated Plga Nps on Tumor Growth: Different Administration Routes}, journal = {Materials Science and Engineering C}, volume = {63}, number = {}, pages = {587-595}, year = {2016} }
RIS	TY - JOUR AU - Fasehee H AU - Zarrinrad G AU - Tavangar SM AU - Ghaffari SH AU - Faghihi S TI - The Inhibitory Effect of Disulfiram Encapsulated Plga Nps on Tumor Growth: Different Administration Routes JO - Materials Science and Engineering C VL - 63 IS - SP - 587 EP - 595 PY - 2016 ER -

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