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The Effect of Ca1 Dopaminergic System in Harmaline-Induced Amnesia Publisher Pubmed



Nasehi M1, 3 ; Ketabchi M2 ; Khakpai F3 ; Zarrindast MR1, 3, 4, 5, 6
Authors
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Authors Affiliations
  1. 1. School of Advanced Sciences in Medicine, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran
  2. 2. Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Northern Branch, Tehran, Iran
  3. 3. Institute for Cognitive Science Studies (ICSS), Tehran, Iran
  4. 4. Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran

Source: Neuroscience Published:2015


Abstract

In the present study, the effects of bilateral injections of dopaminergic drugs into the hippocampal CA1 regions (intra-CA1) on harmaline-induced amnesia were examined in male mice. A one-trial step-down passive avoidance task was used for the assessment of memory retention in adult male mice. Pre-training intra-peritoneal (i.p.) administration of harmaline (1. mg/kg) induced impairment of memory retention. Moreover, intra-CA1 administration of dopamine D1 receptor antagonist, SCH23390 (0.02. μg/mouse), dopamine D1 receptor agonist, SKF38393 (0.5. μg/mouse), dopamine D2 receptor antagonist, sulpiride (1. μg/mouse) and dopamine D2 receptor agonist, quinpirole (0.25 and 0.5. μg/mouse) suppressed the learning of a single-trial passive avoidance task. Also, pre-training intra-CA1 injection of subthreshold doses of SCH23390 (0.001. μg/mouse) or sulpiride (0.25. μg/mouse) with the administration of harmaline (1. mg/kg, i.p.) reversed impairment of memory formation. However, pre-training intra-CA1 injection of SKF38393 (0.1. μg/mouse) or quinpirole (0.1. μg/mouse) increased pre-training harmaline (0.25 and 0.5. mg/kg, i.p.)-induced retrieval impairment. Moreover, SKF Ca blocker (SKF) (0.01. μg/mouse) decrease the amnesia induced by harmaline (1. mg/kg), while co-administration of SKF (0.01. μg/mouse)/sulpiride (0.25. μg/mouse) or SCH23390 (0.001. μg/mouse)/sulpiride (0.25. μg/mouse) potentiate amnesia caused by harmaline. These findings implicate the involvement of CA1 dopaminergic mechanism in harmaline-induced impairment of memory acquisition. © 2014 Published by Elsevier Ltd.
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