Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Influence of Dopaminergic System in Medial Prefrontal Cortex on Ketamine-Induced Amnesia in Passive Avoidance Task in Mice Publisher Pubmed



Farahmandfar M1, 2 ; Bakhtazad A1, 2 ; Akbarabadi A2, 3 ; Zarrindast MR1, 2, 4, 5, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Neuroscience, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Iranian National Center for Addiction Studies, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Basic Sciences, Faculty of Veterinary Medicine, Islamic Azad University, Garmsar Branch, Semnan, Iran
  4. 4. Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Institute for Cognitive Science Studies (ICSS), Tehran, Iran
  6. 6. School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran

Source: European Journal of Pharmacology Published:2016


Abstract

Dopaminergic modulations of glutamate receptors are essential for the prefrontal cortical (PFC) behavioral and cognitive functions. In order to understand the effect of dopamine/glutamate interactions on learning and memory, we investigated the effects of intra medial prefrontal cortex (mPFC) injections of dopaminergic agents on ketamine-induced amnesia by using a one-trial passive avoidance task in mice. Pre-training administration of ketamine (5, 10 and 15 mg/kg, i.p.) dose-dependently decreased the memory acquisition of a one-trial passive avoidance task. Pre-training intra-mPFC administration of SKF 38393, D1 receptor agonist and quinpirol D2 receptor agonist, alone did not affect memory acquisition. However, amnesia induced by pre-training ketamine (15 mg/kg) significantly decreased by pretreatment of SKF 38393 (2 and 4 μg/mouse) and quinpirol (0.3, 1 and 3 μg/mouse). Pre-training administration of SCH 23390, D1 receptor antagonist (0.75 and 1 μg/mouse, intra-mPFC), and sulpiride D2 receptor antagonist (3 μg/mouse, intra-mPFC) impaired memory acquisition. In addition, co-pretreatment of different doses of SCH 23390 and sulpiride with lower dose of ketamine (5 mg/kg), which did not induce amnesia by itself, caused inhibition of memory formation. It may be concluded that dopaminergic system of medial prefrontal cortex is involved in the ketamine-induced impairment of memory acquisition. © 2016 Elsevier B.V.
Experts (# of related papers)
Other Related Docs