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Importance of Linc00852/Mir-145-5P in Breast Cancer: A Bioinformatics and Experimental Study Publisher



Shakoori A1, 2 ; Hosseinzadeh A3 ; Nafisi N4 ; Omranipour R5, 6 ; Sahebi L7 ; Ahmadi M9 ; Ghafourifard S9 ; Abtin M1, 9
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Genetics, Cancer Institute of Iran, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Dr. Qarib St., Keshavarz Blvd, Tehran, Iran
  3. 3. Department of Biology Education, Farhangian University, Tehran, Iran
  4. 4. Surgery Department, Rasoul Akram Hospital, Clinical Research Development Center (RCRDC), Iran University of Medical Sciences, Tehran, Iran
  5. 5. Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Maternal, Fetal and Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran
  9. 9. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Discover Oncology Published:2024


Abstract

Purpose: We aimed to examine the importance of an lncRNA, namely LINC00852, in the pathogenesis of breast cancer. Materials and methods: In the current study, we used several online tools to examine the importance of LINC00852 in breast cancer. Then, we examined these findings in 50 pairs of breast cancer tissues and adjacent non-cancerous ones. We also re-evaluated the data of miR-145-5p signature from our recent study. Results: While in silico tools revealed down-regulation of LINC00852 in breast cancer samples, expression assays showed significant up-regulation of this lncRNAs in breast cancer samples compared with matching control samples from Iranian patients. miR-145-5p was under-expressed in breast cancer samples compared with non-cancerous samples. LINC00852 could separate breast cancer tissues from adjacent non-malignant tissues with an AUC value of 0.7218 (P value < 0.001). Conclusion: The current study potentiates LINC00852/miR-145-5p axis as a possible contributor to the pathogenesis of breast cancer. © The Author(s) 2024.
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