Synthesis, Anti-Proliferative Evaluation, and Molecular Docking Studies of 3-(Alkylthio)-5,6-Diaryl-1,2,4-Triazines As Tubulin Polymerization Inhibitors

Synthesis, Anti-Proliferative Evaluation, and Molecular Docking Studies of 3-(Alkylthio)-5,6-Diaryl-1,2,4-Triazines As Tubulin Polymerization Inhibitors Publisher

Saravani F^{1, 4} ; Moghadam ES¹ ; Salehabadi H¹ ; Ostad S² ; Hamedani MP¹ ; Amanlou M¹ ; Faramarzi MA³ ; Amini M¹

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1. Department of Medicinal Chemistry, Faculty of Pharmacy, Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran

Source: Letters in Drug Design and Discovery Published:2019

Abstract

Background: The role of microtubules in cell division and signaling, intercellular transport, and mitosis has been well known. Hence, they have been targeted for several anti-cancer drugs. Methods: A series of 3-(alkylthio)-5,6-diphenyl-1,2,4-triazines were prepared and evaluated for their cytotoxic activities in vitro against three human cancer cell lines; human colon carcinoma cells HT-29, human breast adenocarcinoma cell line MCF-7, human Caucasian gastric adenocarcinoma cell line AGS as well as fibroblast cell line NIH-3T3 by MTT assay. Docking simulation was performed to insert these compounds into the crystal structure of tubulin at the colchicine binding site to determine a probable binding model. Compound 5d as the most active compound was selected for studying of microtubule disruption. Results: Compound 5d showed potent cytotoxic activity against all cell lines. The molecular modeling study revealed that some derivatives of triazine strongly bind to colchicine binding site. The tubulin polymerization assay kit showed that the cytotoxic activity of 5d may be related to inhibition of tubulin polymerization. Conclusion: The cytotoxicity and molecular modeling study of the synthesized compounds with their inhibition activity in tubulin polymerization demonstrate the potential of triazine derivatives for development of new anti-cancer agents. © 2019 Bentham Science Publishers.

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Mohsen Amini (3)

Seyed Nasser Ostad (2)

Style	Citing Format
MLA	Saravani F, et al.. "Synthesis, Anti-Proliferative Evaluation, and Molecular Docking Studies of 3-(Alkylthio)-5,6-Diaryl-1,2,4-Triazines As Tubulin Polymerization Inhibitors." Letters in Drug Design and Discovery, vol. 16, no. 11, 2019, pp. 1194-1201.
APA	Saravani F, Moghadam ES, Salehabadi H, Ostad S, Hamedani MP, Amanlou M, Faramarzi MA, Amini M (2019). Synthesis, Anti-Proliferative Evaluation, and Molecular Docking Studies of 3-(Alkylthio)-5,6-Diaryl-1,2,4-Triazines As Tubulin Polymerization Inhibitors. Letters in Drug Design and Discovery, 16(11), 1194-1201.
Chicago	Saravani F, Moghadam ES, Salehabadi H, Ostad S, Hamedani MP, Amanlou M, Faramarzi MA, Amini M. "Synthesis, Anti-Proliferative Evaluation, and Molecular Docking Studies of 3-(Alkylthio)-5,6-Diaryl-1,2,4-Triazines As Tubulin Polymerization Inhibitors." Letters in Drug Design and Discovery 16, no. 11 (2019): 1194-1201.
Harvard	Saravani F et al. (2019) 'Synthesis, Anti-Proliferative Evaluation, and Molecular Docking Studies of 3-(Alkylthio)-5,6-Diaryl-1,2,4-Triazines As Tubulin Polymerization Inhibitors', Letters in Drug Design and Discovery, 16(11), pp. 1194-1201.
Vancouver	Saravani F, Moghadam ES, Salehabadi H, Ostad S, Hamedani MP, Amanlou M, et al.. Synthesis, Anti-Proliferative Evaluation, and Molecular Docking Studies of 3-(Alkylthio)-5,6-Diaryl-1,2,4-Triazines As Tubulin Polymerization Inhibitors. Letters in Drug Design and Discovery. 2019;16(11):1194-1201.
BibTex	@article{ author = {Saravani F and Moghadam ES and Salehabadi H and Ostad S and Hamedani MP and Amanlou M and Faramarzi MA and Amini M}, title = {Synthesis, Anti-Proliferative Evaluation, and Molecular Docking Studies of 3-(Alkylthio)-5,6-Diaryl-1,2,4-Triazines As Tubulin Polymerization Inhibitors}, journal = {Letters in Drug Design and Discovery}, volume = {16}, number = {11}, pages = {1194-1201}, year = {2019} }
RIS	TY - JOUR AU - Saravani F AU - Moghadam ES AU - Salehabadi H AU - Ostad S AU - Hamedani MP AU - Amanlou M AU - Faramarzi MA AU - Amini M TI - Synthesis, Anti-Proliferative Evaluation, and Molecular Docking Studies of 3-(Alkylthio)-5,6-Diaryl-1,2,4-Triazines As Tubulin Polymerization Inhibitors JO - Letters in Drug Design and Discovery VL - 16 IS - 11 SP - 1194 EP - 1201 PY - 2019 ER -

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