Synthesis and Anticancer Activity of 1,3,5-Triaryl-1H-Pyrazole

Synthesis and Anticancer Activity of 1,3,5-Triaryl-1H-Pyrazole Publisher

Ghadbeigi S¹ ; Ostad SN³ ; Shafiee A¹ ; Amini M^{1, 2}

Show Affiliations

1. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Letters in Drug Design and Discovery Published:2015

Abstract

Previous studies demonstrated that some pyrazole derivatives could be considered as potential anticancer agents. A series of 1,3,5-triaryl-1H-pyrazole derivatives were prepared by the reaction of phenylhydrazin and different chalcones. The previous classic synthesis method was developed for a simpler procedure. The cytotoxicity of these compounds was determined against three cancer cell lines (HT-29), (MCF-7), (AGS) as well as fibroblastic cell line (NIH-3T3) using MTT assay. These biological studies proved that 5f and 5l were the most potent compounds in this series. Furthermore, 5f showed a partial selectivity in cytotoxicity effect between the cancerous and normal cell lines. © 2015 Bentham Science Publishers.

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Mohsen Amini (9)

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Style	Citing Format
MLA	Ghadbeigi S, et al.. "Synthesis and Anticancer Activity of 1,3,5-Triaryl-1H-Pyrazole." Letters in Drug Design and Discovery, vol. 12, no. 9, 2015, pp. 754-759.
APA	Ghadbeigi S, Ostad SN, Shafiee A, Amini M (2015). Synthesis and Anticancer Activity of 1,3,5-Triaryl-1H-Pyrazole. Letters in Drug Design and Discovery, 12(9), 754-759.
Chicago	Ghadbeigi S, Ostad SN, Shafiee A, Amini M. "Synthesis and Anticancer Activity of 1,3,5-Triaryl-1H-Pyrazole." Letters in Drug Design and Discovery 12, no. 9 (2015): 754-759.
Harvard	Ghadbeigi S et al. (2015) 'Synthesis and Anticancer Activity of 1,3,5-Triaryl-1H-Pyrazole', Letters in Drug Design and Discovery, 12(9), pp. 754-759.
Vancouver	Ghadbeigi S, Ostad SN, Shafiee A, Amini M. Synthesis and Anticancer Activity of 1,3,5-Triaryl-1H-Pyrazole. Letters in Drug Design and Discovery. 2015;12(9):754-759.
BibTex	@article{ author = {Ghadbeigi S and Ostad SN and Shafiee A and Amini M}, title = {Synthesis and Anticancer Activity of 1,3,5-Triaryl-1H-Pyrazole}, journal = {Letters in Drug Design and Discovery}, volume = {12}, number = {9}, pages = {754-759}, year = {2015} }
RIS	TY - JOUR AU - Ghadbeigi S AU - Ostad SN AU - Shafiee A AU - Amini M TI - Synthesis and Anticancer Activity of 1,3,5-Triaryl-1H-Pyrazole JO - Letters in Drug Design and Discovery VL - 12 IS - 9 SP - 754 EP - 759 PY - 2015 ER -

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