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Mitochondrial Quality Control and Melatonin: A Strategy Against Myocardial Injury Publisher Pubmed



Ghavamikia N1 ; Mehrnoosh F2 ; Zare F3 ; Alikhiavi P3 ; Sinehsepehr A4 ; Boushehri YG5 ; Vahedinezhad M6 ; Abdollahi E6 ; Hjazi A7 ; Aminnezhad S8, 9 ; Saffarfar H8, 9 ; Hamzehzadeh S3 ; Nourizadeh M10 ; Karkonshayan S11
Authors
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Authors Affiliations
  1. 1. Cardiovascular Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Food Science and Technology, Faculty of Agriculture and Natural Resources, Urmia University, Urmia, Iran
  3. 3. Student Research Committee, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
  5. 5. Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Cardiovascular Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia
  8. 8. Cardiovascular Research Center, Tehran, Iran
  9. 9. Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  11. 11. Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Journal of Biochemical and Molecular Toxicology Published:2025


Abstract

Melatonin exhibits various biological functions, including regulation of circadian and endocrine rhythms, anti-inflammatory, and antioxidant effects. Aging and damaged mitochondria are major sources of oxidative stress (OS), and mitochondrial quality control (MQC) is crucial for maintaining normal mitochondrial function. Myocardial ischemia-reperfusion injury is a major complication that can arise during reperfusion therapy for coronary heart disease. However, effective intervention strategies are currently lacking. Mitochondrial dysfunction and OS are considered central mechanisms of myocardial reperfusion injury, with mitochondrial-targeted interventions being a potential treatment direction. Recent studies have shown that melatonin improves mitochondrial structure and function through multiple pathways. This review discusses the mechanisms by which melatonin ameliorates myocardial ischemia-reperfusion injury, focusing on MQC, and explores its potential applications in the prevention and treatment of myocardial ischemia-reperfusion injury. © 2025 Wiley Periodicals LLC.
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