Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Sleep Profiles in Epilepsy Patients Undergoing Monotherapy and Polytherapy: A Comparative Cross-Sectional Study Publisher Pubmed



Arvin A1, 5 ; Taebi M1, 6 ; Khazaeipour Z3 ; Najafi A4 ; Tafakhori A2 ; Ranjibourachaloo S2 ; Amirifard H2
Authors

Source: Epilepsy and Behavior Published:2024


Abstract

Objective: Sleep disturbances commonly reported among epilepsy patients have a reciprocal relationship with the condition; While epilepsy and anti-seizure medications (ASMs) can disrupt sleep structure, disturbed sleep can also exacerbate the frequency of seizures. This study explored subjective sleep disturbances and compared sleep profiles in patients who underwent ASM monotherapy and polytherapy. Methods: We enrolled 176 epilepsy patients who completed a structured questionnaire containing demographic and clinical information and the Persian versions of the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and Patient Health Questionnaire-9 (PHQ-9) to evaluate sleep quality, insomnia, excessive daytime sleepiness (EDS), and depressive symptoms, respectively. Chi-square and Mann-Whitney U tests were employed to analyze the association between variables, and logistic regression analysis was conducted to identify factors predicting sleep disturbances. Results: Comparative analysis of mono/polytherapy groups revealed a significantly higher prevalence of insomnia and EDS among patients on polytherapy compared to monotherapy. However, no significant difference was found in sleep quality between the two groups. Logistic regression analysis revealed that a depressive mood serves as a robust predictor for sleep issues, whereas treatment type did not emerge as an independent predictor of sleep disturbances. Conclusion: Our findings suggest that an increased number of ASMs does not inherently result in a higher incidence of sleep issues. Therefore, multiple ASMs may be prescribed when necessary to achieve improved seizure control. Furthermore, this study underscores the importance of comprehensive management that addresses seizure control and treating affective symptoms in individuals with epilepsy. © 2024 Elsevier Inc.
Related Docs
View other Related Docs
1. Validity and Reliability of the Dysfunctional Beliefs and Attitudes About Sleep Scale-10 in Iranian Clinical Population, Iranian Journal of Psychiatry and Behavioral Sciences (2018)
2. Validity and Reliability of the Persian Version of the Insomnia Diurnal Impact Scale (Idis), Sleep and Breathing (2021)
3. Sleep Disturbance in Alopecia Areata: A Cross-Sectional Study, Health Science Reports (2022)
Experts (# of related papers)
View all Related Experts
Khosro Sadeghniat (6)
Samaneh Akbarpour (4)
Other Related Docs
4. Effects of Treatment of Sleep Disorders on Sleep, Psychological and Cognitive Functioning and Biomarkers in Individuals With Hiv/Aids and Under Methadone Maintenance Therapy, Journal of Psychiatric Research (2020)
5. Glasgow Sleep Effort Scale: Translation, Test, and Evaluation of Psychometric Properties of the Persian Version, Nature and Science of Sleep (2020)
6. Components of Pittsburgh Sleep Quality Index in Iranian Adult Population: An Item Response Theory Model, Sleep Medicine: X (2021)
7. Acceptance and Commitment Therapy (Act) Improves Sleep Quality, Experiential Avoidance, and Emotion Regulation in Individuals With Insomnia—Results From a Randomized Interventional Study, Life (2021)
8. Sleep Characteristics of Iranian People and Their Effects on Daytime Functioning: A Population-Based Study, Scientific Reports (2022)
9. Sleep Quality and Its Association With Psychological Distress and Sleep Hygiene: A Crosssectional Study Among Pre-Clinical Medical Students, Sleep Science (2018)
10. The Effect of Group Cognitive Behavioural Therapy for Insomnia in Postmenopausal Women, Journal of Sleep Research (2021)
11. Sleep Quality and Associated Factors Among People Who Inject Drugs in Iran: A Nationwide Survey Using Respondent-Driven Sampling, BMC Public Health (2024)
12. Comparing the Effects of Melatonin and Zolpidem on Sleep Quality, Depression, and Anxiety in Patients With Colorectal Cancer Under Going Chemotherapy, Basic and Clinical Neuroscience (2021)
13. Association Between Psychological Discomforts and Sleep Quality Among People Living With Hiv/Aids, AIDS Research and Therapy (2023)
14. Aloysia Citriodora Palau (Lemon Verbena) for Insomnia Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Efficacy and Safety, Phytotherapy Research (2019)
15. Effect of Melatonin on Insomnia and Daytime Sleepiness, in Patients With Obstructive Sleep Apnea and Insomnia (Comisa): A Randomized Double-Blinded Placebo-Controlled Trial, Journal of Pharmaceutical Health Care and Sciences (2024)
16. Efficacy of Vitamins B1 and B6 As an Adjunctive Therapy to Lithium in Bipolar-I Disorder: A Double-Blind, Randomized, Placebo-Controlled, Clinical Trial, Journal of Affective Disorders (2024)
17. Visual Attention and Poor Sleep Quality, Frontiers in Neuroscience (2022)
18. The Relation of Sleep Characteristics and Cognitive Impairment in Community-Dwelling Middle-Aged and Older Adults: Ardakan Cohort Study on Aging (Acsa), Dementia and Geriatric Cognitive Disorders Extra (2024)
19. Psychometric Evaluation of Persian Version of Seizure Severity Questionnaire, Epilepsy and Behavior (2022)
20. Comparison of Prevalence Rates of Restless Legs Syndrome, Self-Assessed Risks of Obstructive Sleep Apnea, and Daytime Sleepiness Among Patients With Multiple Sclerosis (Ms), Clinically Isolated Syndrome (Cis) and Neuromyelitis Optica Spectrum Disorder (Nmosd), Sleep Medicine (2020)