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The Effect of Platelet-Rich Fibrin (Prf) Versus Freeze-Dried Bone Allograft (Fdba) Used in Alveolar Ridge Preservation on the Peri-Implant Soft and Hard Tissues: A Randomized Clinical Trial Publisher Pubmed



Azangookhiavi H1 ; Habibzadeh S1, 2 ; Zahmatkesh H3 ; Mellati E4, 5 ; Mosaddad SA6, 8 ; Dadpour Y7
Authors
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Authors Affiliations
  1. 1. Department of Prosthodontics, School of Dentistry, Tehran University of Medical Sciences, International Campus, Tehran, Iran
  2. 2. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Private Practice, Tehran, Iran
  4. 4. University of Sydney, Sydney, Australia
  5. 5. Private Practice, Sydney, Australia
  6. 6. Department of Research Analytics, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Saveetha University, Chennai, India
  7. 7. Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, International Campus, Tehran, Iran
  8. 8. Department of Conservative Dentistry and Bucofacial Prosthesis, Faculty of Odontology, Complutense University of Madrid, Madrid, Spain

Source: BMC Oral Health Published:2024


Abstract

Background: The effectiveness of alveolar ridge preservation on bone regeneration and tissue healing has been thoroughly documented in the literature. This study aimed to evaluate the peri-implant soft and hard tissue changes after alveolar ridge preservation using either platelet-rich fibrin (PRF) or freeze-dried bone allograft (FDBA) over a 12-month period following the prosthetic loading of implants. Methods: In this randomized clinical trial, 40 individuals were recruited for alveolar ridge preservation using (1) FDBA or (2) PRF in incisal/premolar areas. At two follow-up sessions (six- and 12-months post-implant insertion), radiographic imaging and clinical examinations assessed marginal bone loss and soft tissue factors, including gingival recession and bleeding on probing. The differences between study groups were analyzed using Generalized estimating Equations, the Binary logistic regression model, and Cochran’s Q test. Results: There was a statistically significant difference regarding gingival recession at both follow-up evaluations; values in the PRF group were considerably lower compared to the FDBA group (p < 0.05). The mean values for vertical marginal bone loss and bleeding on probing showed no significant differences between the two study groups (p > 0.05). Conclusions: Except for gingival recession, applying PRF yielded comparable clinical results to FDBA after one year of implant loading and could be recommended as a potential biomaterial for alveolar ridge preservation following tooth extractions. Clinical trial registration: The research protocol was registered in the Protocol Registration and Results System on 13/08/2021, available at https://clinicaltrials.gov/ (NCT05005377). © The Author(s) 2024.
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