New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Share By

New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies Publisher

Esfahani EN¹ ; Mohammadikhanaposhtani M² ; Rezaei Z³ ; Valizadeh Y³ ; Rajabnia R⁴ ; Hassankalhori M⁵ ; Bandarian F¹ ; Faramarzi MA^{6, 7} ; Samadi N^{8, 9} ; Amini MR¹ ; Mahdavi M¹ ; Larijani B¹

Source: Research on Chemical Intermediates Published:2019

Abstract

We designed and synthesized a series of new ciprofloxacin–dithiocarbamate–benzyl hybrids 5a–n as potential antibacterial agents. All of the synthesized compounds were screened for in vitro antibacterial activity against four bacterial strains (Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa). The antibacterial results indicated that some of the synthesized compounds showed remarkable activity, comparable to their parent drug ciprofloxacin. Among the synthesized compounds, the 4-nitro derivative 5n, exhibited the most antibacterial activity against S. aureus, S. epidermidis, and E. coli. The antibacterial activity of this compound against S. aureus and E. coli was twofold higher than that of its parent ciprofloxacin. Molecular modeling of compound 5n was also investigated in the active site of E. coli DNA gyrase. © 2018, Springer Nature B.V.

Related Docs

View other Related Docs

1. Biology-Oriented Drug Synthesis (Biods) Approach Towards Synthesis of Ciprofloxacin-Dithiocarbamate Hybrids and Their Antibacterial Potential Both in Vitro and in Silico, Chemistry and Biodiversity (2018)

2. Novel Levofloxacin Derivatives As Potent Antibacterial Agents, Journal of Sciences# Islamic Republic of Iran (2017)

3. New Antimicrobial Nitro Heteroaryl-1,3,4-Thiadiazole Derivatives Containing Piperazinyl Benzonitrile Moiety: Synthesis and in Silico Study, Journal of Computational Biophysics and Chemistry (2022)

Experts (# of related papers)

View all Related Experts

Alireza Foroumadi (8)

Mohammad Mahdavi (4)

Other Related Docs

4. Synthesis of New 2-(5-(5-Nitrofuran-2-Yl)-1,3,4-Thiadiazol-2-Ylimino)Thiazolidin-4-One Derivatives As Anti-Mrsa and Anti-H. Pylori Agents, BMC Chemistry (2022)

5. Synthesis and Docking Study of Novel 4-Thiazolidinone Derivatives As Anti-Gram-Positive and Anti-H. Pylori Agents, Mini-Reviews in Medicinal Chemistry (2019)

6. Design and Synthesis of New N-Thioacylated Ciprofloxacin Derivatives As Urease Inhibitors With Potential Antibacterial Activity, Scientific Reports (2022)

7. Novel Fluoroquinolones Analogues Bearing 4-(Arylcarbamoyl)Benzyl: Design, Synthesis, and Antibacterial Evaluation, Molecular Diversity (2023)

8. New 7-Piperazinylquinolones Containing (Benzo[D]Imidazol-2-Yl)Methyl Moiety As Potent Antibacterial Agents, Molecular Diversity (2018)

9. In-Vitro Antibacterial Evaluation of Some Fluoroquinolone Derivatives Against Food Borne Bacteria, Journal of Sciences# Islamic Republic of Iran (2016)

10. Preparation and Optimization of Ciprofloxacin Encapsulated Niosomes: A New Approach for Enhanced Antibacterial Activity, Biofilm Inhibition and Reduced Antibiotic Resistance in Ciprofloxacin-Resistant Methicillin-Resistance Staphylococcus Aureus, Bioorganic Chemistry (2020)

11. Design, Synthesis, Molecular Docking Study, and Antibacterial Evaluation of Some New Fluoroquinolone Analogues Bearing a Quinazolinone Moiety, DARU# Journal of Pharmaceutical Sciences (2020)

12. Structure-Based Drug Discovery and Antimicrobial Activity of Ciprofloxacin‐Grafted Ugi Adducts, Journal of Biomolecular Structure and Dynamics (2023)

13. Antibacterial Activity of Gold Nanoparticles Conjugated by Aminoglycosides Against A. Baumannii Isolates From Burn Patients, Recent Patents on Anti-Infective Drug Discovery (2018)

14. In Vitro Antimicrobial Activity of Dermcidin-1L Against Extensively-Drug-Resistant and Pandrug-Resistant Acinetobacter Baumannii, Jundishapur Journal of Microbiology (2017)

15. Photoelimination Potential of Chitosan Nanoparticles-Indocyanine Green Complex Against the Biological Activities of Acinetobacter Baumannii Strains: A Preliminary in Vitro Study in Burn Wound Infections, Journal of Lasers in Medical Sciences (2020)

16. Antibacterial, Antibiofilm, Anti-Inflammatory, and Wound Healing Effects of Nanoscale Multifunctional Cationic Alternating Copolymers, Bioorganic Chemistry (2022)

17. New Coumarin Derivatives From Ferula Pseudalliacea With Antibacterial Activity, Natural Product Research (2016)

18. Design, Synthesis and Evaluation of Antitubercular Activity of Novel Dihydropyridine Containing Imidazolyl Substituent, Iranian Journal of Pharmaceutical Research (2015)

19. In Silico and in Vitro Insights Into the Prediction and Analysis of Natural Photosensitive Compounds Targeting Acinetobacter Baumannii Biofilm-Associated Protein, Photodiagnosis and Photodynamic Therapy (2022)

20. Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives, Journal of Heterocyclic Chemistry (2020)

Style	Citing Format
MLA	Esfahani EN, et al.. "New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies." Research on Chemical Intermediates, vol. 45, no. 2, 2019, pp. 223-236.
APA	Esfahani EN, Mohammadikhanaposhtani M, Rezaei Z, Valizadeh Y, Rajabnia R, Hassankalhori M, Bandarian F, Faramarzi MA, Samadi N, Amini MR, Mahdavi M, Larijani B (2019). New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies. Research on Chemical Intermediates, 45(2), 223-236.
Chicago	Esfahani EN, Mohammadikhanaposhtani M, Rezaei Z, Valizadeh Y, Rajabnia R, Hassankalhori M, Bandarian F, et al.. "New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies." Research on Chemical Intermediates 45, no. 2 (2019): 223-236.
Harvard	Esfahani EN et al. (2019) 'New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies', Research on Chemical Intermediates, 45(2), pp. 223-236.
Vancouver	Esfahani EN, Mohammadikhanaposhtani M, Rezaei Z, Valizadeh Y, Rajabnia R, Hassankalhori M, et al.. New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies. Research on Chemical Intermediates. 2019;45(2):223-236.
BibTex	@article{ author = {Esfahani EN and Mohammadikhanaposhtani M and Rezaei Z and Valizadeh Y and Rajabnia R and Hassankalhori M and Bandarian F and Faramarzi MA and Samadi N and Amini MR and Mahdavi M and Larijani B}, title = {New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies}, journal = {Research on Chemical Intermediates}, volume = {45}, number = {2}, pages = {223-236}, year = {2019} }
RIS	TY - JOUR AU - Esfahani EN AU - Mohammadikhanaposhtani M AU - Rezaei Z AU - Valizadeh Y AU - Rajabnia R AU - Hassankalhori M AU - Bandarian F AU - Faramarzi MA AU - Samadi N AU - Amini MR AU - Mahdavi M AU - Larijani B TI - New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies JO - Research on Chemical Intermediates VL - 45 IS - 2 SP - 223 EP - 236 PY - 2019 ER -

Science Communicator Platform

Authors

Abstract