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A Review on Synthesis, Mechanism of Action, and Structure-Activity Relationships of 1,2,3-Triazole-Based Α-Glucosidase Inhibitors As Promising Anti-Diabetic Agents Publisher



Fallah Z1 ; Tajbakhsh M1 ; Alikhani M2 ; Larijani B3 ; Faramarzi MA4 ; Hamedifar H5 ; Mohammadikhanaposhtani M6 ; Mahdavi M3
Authors

Source: Journal of Molecular Structure Published:2022


Abstract

α-Glucosidase is a key enzyme in hydrolysis of carbohydrates to glucose and located in the small intestine brush border. Inhibition of this enzyme delay the release of glucose and therefore α-glucosidase inhibitors are considered as attractive drugs for treatment of diabetes as a carbohydrate-related disorder. Due to the importance of α-glucosidase inhibitors in the treatment of diabetes, the discovery and development of new safe and efficient inhibitors for α-glucosidase is an attractive topic for medicinal chemists. In the last decade, 1,2,3-triazole-based derivatives have found much interest in this research field. The click reaction is the most potent tool for easy construction for synthesis of hybrid molecules of 1,2,3-triazole ring and other effective pharmacophors in α-glucosidase inhibition. Herein, an overview is reported on synthesis, biological evaluations, and structure-activity relationships of the reported α-glucosidase inhibitors containing 1,2,3-triazole ring. © 2022 Elsevier B.V.
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