Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Cell Therapy in Transplantation: A Comprehensive Review of the Current Applications of Cell Therapy in Transplant Patients With the Focus on Tregs, Car Tregs, and Mesenchymal Stem Cells Publisher Pubmed



Mansourabadi AH1, 2, 3 ; Mohamed Khosroshahi L1 ; Noorbakhsh F1 ; Amirzargar A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, 009821, Iran
  2. 2. Network of Immunity in Infection, Malignancy, and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, 009821, Iran
  3. 3. Systematic Review and Meta-Analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, 009821, Iran

Source: International Immunopharmacology Published:2021


Abstract

Organ transplantation is a practical treatment for patients with end-stage organ failure. Despite the advances in short-term graft survival, long-term graft survival remains the main challenge considering the increased mortality and morbidity associated with chronic rejection and the toxicity of immunosuppressive drugs. Since a novel therapeutic strategy to induce allograft tolerance seems urgent, focusing on developing novel and safe approaches to prolong graft survival is one of the main goals of transplant investigators. Researchers in the field of organ transplantation are interested in suppressing or optimizing the immune responses by focusing on immune cells including mesenchymal stem cells (MSCs), polyclonal regulatory Tcells (Tregs), and antigen-specific Tregs engineered with chimeric antigen receptors (CAR Tregs). We review the mechanistic pathways, phenotypic and functional characteristics of these cells, and their promising application in organ transplantation. © 2021
Related Docs
View other Related Docs
1. Overview and Recent Advances of Regulatory T Cell Therapy in Solid Organ Transplantation, Iranian Journal of Kidney Diseases (2021)
2. The Therapeutic Potential of Regulatory T Cells: Challenges and Opportunities, Frontiers in Immunology (2021)
3. Chimeric Antigen Receptor -T Cell Therapy: Applications and Challenges in Treatment of Allergy and Asthma, Biomedicine and Pharmacotherapy (2020)
4. Genetically Engineered Mesenchymal Stromal Cells As a New Trend for Treatment of Severe Acute Graft-Versus-Host Disease, Clinical and Experimental Immunology (2022)
5. Identification, Isolation, and Functional Assay of Regulatory T Cells, Immunological Investigations (2016)
6. Emerging Therapeutic Potential of Regulatory T (Treg) Cells for Rheumatoid Arthritis: New Insights and Challenges, International Immunopharmacology (2022)
7. Transplant and Kidney Repair, Stem Cells in Urology (2020)
8. Evaluation of Safety and Efficacy of Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells in Pediatric Bronchiolitis Obliterans Syndrome (Bos) After Allogeneic Hematopoietic Stem Cell Transplantation (Allo-Hsct), Stem Cell Research and Therapy (2023)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (6)
Ali Akbar Amirzargar (4)
Other Related Docs
9. Utilization of Mesenchymal Stem Cells in Kidney Transplantation: From Bench to Bedside, Iranian Journal of Kidney Diseases (2019)
10. The Role of Mesenchymal Stem Cells in Atherosclerosis: Prospects for Therapy Via the Modulation of Inflammatory Milieu, Journal of Clinical Medicine (2019)
11. Autoimmune Diseases, Clinical Immunology (2022)
12. Co-Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells With Hematopoietic Stem Cells Does Not Improve Transplantation Outcome in Class Iii Beta-Thalassemia Major: A Prospective Cohort Study With Long-Term Follow-Up, Pediatric Transplantation (2021)
13. Autoimmunity As a Target for Chimeric Immune Receptor Therapy: A New Vision to Therapeutic Potential, Blood Reviews (2020)
14. The Role of T Helper 17 and Regulatory T Cells in Tumor Microenvironment, Immunopharmacology and Immunotoxicology (2019)
15. Adoptive Treg Cell-Based Immunotherapy: Frontier Therapeutic Aspects in Rheumatoid Arthritis, Immunotherapy (2020)
16. Mesenchymal Stem Cells: Rising Concerns Over Their Application in Treatment of Type One Diabetes Mellitus, Journal of Diabetes Research (2015)
17. Sirolimus Vs Mycophenolate Moftile in Tacrolimus Based Therapy Following Induction With Antithymocyte Globulin Promotes Regulatory T Cell Expansion and Inhibits Rorγt and T-Bet Expression in Kidney Transplantation, Human Immunology (2019)
18. Clinical and Diagnostic Potential of Regulatory T Cell Markers: From Bench to Bedside, Transplant Immunology (2022)
19. Regulatory T Cells in Breast Cancer As a Potent Anti-Cancer Therapeutic Target, International Immunopharmacology (2020)
20. Protective and Pathological Roles of Regulatory Immune Cells in Human Cytomegalovirus Infection Following Hematopoietic Stem Cell Transplantation, Reviews in Medical Virology (2022)
21. Genetically Engineered Adipose Mesenchymal Stem Cells Using Hiv-Based Lentiviral Vectors As Gene Therapy for Autoimmune Diseases, Cellular Reprogramming (2018)
22. Therapeutic and Immunomodulatory Potentials of Mesenchymal Stromal/Stem Cells and Immune Checkpoints Related Molecules, Biomarker Research (2024)
23. Immunopathology of Type 1 Diabetes and Immunomodulatory Effects of Stem Cells: A Narrative Review of the Literature, Endocrine# Metabolic and Immune Disorders - Drug Targets (2022)
24. Recent Progress in Cell Therapy in Solid Organ Transplantation, International Journal of Organ Transplantation Medicine (2017)
25. Isolation and in Vitro Expansion of Regulatory T Cells From Β-Thalassemia Major Kids and in Vitro Evaluation of Their Plasticity and Inhibitory Effects in the Presence of Pro-Inflammatory Cytokines, International Archives of Allergy and Immunology (2023)
26. E3 Ubiquitin Ligase Casitas B Lineage Lymphoma-B and Its Potential Therapeutic Implications for Immunotherapy, Clinical and Experimental Immunology (2021)
27. The Role of Interleukin-2 in Graft-Versus-Host Disease Pathogenesis, Prevention and Therapy, Cytokine (2024)
28. The Critical Role of Mesenchymal Stromal/Stem Cell Therapy in Covid-19 Patients: An Updated Review, Cell Biochemistry and Function (2021)
29. Cancer Immunology, Encyclopedia of Infection and Immunity (2022)
30. Solid Tumors Challenges and New Insights of Car T Cell Engineering, Stem Cell Reviews and Reports (2019)
31. Gene-Knocked Out Chimeric Antigen Receptor (Car) T Cells: Tuning up for the Next Generation Cancer Immunotherapy, Cancer Letters (2018)
32. What Is Novel in the Clinical Management of Pemphigus Vulgaris?, Expert Review of Clinical Pharmacology (2024)
33. Effect of Microrna-21 Transfection on In-Vitro Differentiation of Human Naive Cd4+ T Cells to Regulatory T Cells, Iranian Journal of Allergy# Asthma and Immunology (2017)
34. The Paths and Challenges of “Off-The-Shelf” Car-T Cell Therapy: An Overview of Clinical Trials, Biomedicine and Pharmacotherapy (2023)
35. Transplantation, Clinical Immunology (2022)
36. The Effect of Il-22 and Il-28 in Induction of Type 1 Regulatory T (Tr1) Cells, Iranian Journal of Allergy# Asthma and Immunology (2015)
37. Liver Fibrosis Alleviation After Co-Transplantation of Hematopoietic Stem Cells With Mesenchymal Stem Cells in Patients With Thalassemia Major, Annals of Hematology (2018)
38. Altered Microrna Expression and Immunosuppressive Cytokine Production by Regulatory T Cells of Ulcerative Colitis Patients, Immunological Investigations (2016)
39. A Deep Insight Into Crispr/Cas9 Application in Car-T Cell-Based Tumor Immunotherapies, Stem Cell Research and Therapy (2021)
40. Evaluation of Il-17 Producing Memory Regulatory and Effector T Cells Expressing Cd26 Molecule in Patients With Psoriasis, Iranian Journal of Allergy# Asthma and Immunology (2018)
41. Mesenchymal Stem Cells and Natural Killer Cells Interaction Mechanisms and Potential Clinical Applications, Stem Cell Research and Therapy (2022)
42. Neurological Adverse Effects of Chimeric Antigen Receptor T-Cell Therapy, Expert Review of Clinical Immunology (2023)
43. Challenges in Mesenchymal Stromal Cell-Based Therapies, Current Stem Cell Research and Therapy (2023)
44. Immunomodulatory and Protective Effects of Adipose Tissue-Derived Mesenchymal Stem Cells in an Allograft Islet Composite Transplantation for Experimental Autoimmune Type 1 Diabetes, Immunology Letters (2017)
45. Introduction, Stem Cells in Urology (2020)
46. Effects of Polybrene and Retronectin As Transduction Enhancers on the Development and Phenotypic Characteristics of Vhh-Based Cd19-Redirected Car T Cells: A Comparative Investigation, Clinical and Experimental Medicine (2023)
47. Car T Cell Therapy in Solid Tumors; With an Extensive Focus on Obstacles and Strategies to Overcome the Challenges, International Immunopharmacology (2021)
48. F Protein Increases Cd4+Cd25+ T Cell Population in Patients With Chronic Hepatitis C, Pathogens and Disease (2015)
49. Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Ace Card to Address Autoimmune Diseases, International Journal of Stem Cells (2020)
50. The Current Landscape of Car T-Cell Therapy for Solid Tumors: Mechanisms, Research Progress, Challenges, and Counterstrategies, Frontiers in Immunology (2023)