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Adoptive Treg Cell-Based Immunotherapy: Frontier Therapeutic Aspects in Rheumatoid Arthritis Publisher Pubmed



Zavvar M1, 2 ; Assadiasl S3 ; Zargaran S4 ; Akhtari M5 ; Poopak B6 ; Dinarvand R7, 8 ; Fatahi Y7, 8 ; Tayebi L9 ; Soleimanifar N3 ; Nicknam MH2, 3
Authors
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Authors Affiliations
  1. 1. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Molecular Immunology Research Centre, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Faculty of Paramedical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  5. 5. Department of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran
  6. 6. Department of Hematology, Faculty of Paramedical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  7. 7. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Marquette University School of Dentistry, Milwaukee, 53233, WI, United States

Source: Immunotherapy Published:2020


Abstract

The major current focus on treating rheumatoid arthritis is to put an end to long-term treatments and instead, specifically block widespread immunosuppression by developing antigen-specific tolerance, while also permitting an intact immune response toward other antigens to occur. There have been promising preclinical findings regarding adoptive Treg cells immunotherapy with a critically responsible function in the prevention of autoimmunity, tissue repair and regeneration, which make them an attractive candidate to develop effective therapeutic approaches to achieve this interesting concept in many human immune-mediated diseases, such as rheumatoid arthritis. Ex vivo or invivo manipulation protocols are not only utilized to correct Treg cells defect, but also to benefit from their specific immunosuppressive properties by identifying specific antigens that are expressed in the inflamedjoint. The methods able to address these deficiencies can be considered as a target for immunity interventions to restore appropriate immune function. © 2020 Future Medicine Ltd.. All rights reserved.
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