Study of Therapeutic Results, Lymph Node Ratio, Short-Term and Long-Term Complications of Lateral Lymph Node Dissection in Rectal Cancer Patients

Study of Therapeutic Results, Lymph Node Ratio, Short-Term and Long-Term Complications of Lateral Lymph Node Dissection in Rectal Cancer Patients Publisher

Summary: Could TME and LLND improve survival rates in rectal cancer? Study shows promising outcomes in women. Further evaluation needed for standard care. #CancerSurgery #RectalCancer

Mahmoodzadeh H¹ ; Omranipour R¹ ; Borjian A¹ ; Borjian MA¹

Source: Turkish Journal of Surgery Published:2020

Abstract

Objective: This study aimed to assess disease free survival, lymph node ratio (LNR) and complication rate among advanced mid to low rectal cancer patients (stage 2-3) who underwent total mesorectal excision (TME) and lateral lymph node dissection (LLND) at the Iran Cancer Institute in 2016-2018. Material and Methods: The study was carried out on 32 patients treated by curative surgery and lateral lymph node dissection at the Iran Cancer Institute from 2016 March to 2018 March. Chi-square test was used to assess the distribution of dichotomous clinical outcomes by sex. We also used Breslow test in Kaplan-Meier approach to estimate 1-year disease free survival and corresponding 95% confidence intervals (CI). Results: Of the 279 dissected lymph nodes by TME, 42 nodes (in mesorectal) and of the 232 dissected lymph nodes by LLND, 7 nodes (in iliac, para-iliac and obturator) were positive for metastasis. Higher local recurrence was observed in men (three patients) compared to women (one patient) which was not statistically significant (p= 0.878). We also observed higher 1-year disease free survival rate in women (1-year disease free survival= 93.3%) compared to men (1-year disease free survival= 82.4%), which also was not statistically significant (p= 0.356). 1-year disease free survival rate in patient with negative lymph nodes was 95.5% while respective number in patients with positive lymph nodes was 70% (p= 0.047). Conclusion: TME with LLND could prolong survival and reduce local recurrence in patients with advanced low rectal cancer. However, large-scale clinical trials are required to evaluate such procedure as a standard in Iran. © 2020 Bilimsel Tip Yayinevi. All rights reserved.

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Study of Therapeutic Results, Lymph Node Ratio, Short-Term and Long-Term Complications of Lateral Lymph Node Dissection in Rectal Cancer Patients

Style	Citing Format
MLA	Mahmoodzadeh H, et al.. "Study of Therapeutic Results, Lymph Node Ratio, Short-Term and Long-Term Complications of Lateral Lymph Node Dissection in Rectal Cancer Patients." Turkish Journal of Surgery, vol. 36, no. 2, 2020, pp. 224-228.
APA	Mahmoodzadeh H, Omranipour R, Borjian A, Borjian MA (2020). Study of Therapeutic Results, Lymph Node Ratio, Short-Term and Long-Term Complications of Lateral Lymph Node Dissection in Rectal Cancer Patients. Turkish Journal of Surgery, 36(2), 224-228.
Chicago	Mahmoodzadeh H, Omranipour R, Borjian A, Borjian MA. "Study of Therapeutic Results, Lymph Node Ratio, Short-Term and Long-Term Complications of Lateral Lymph Node Dissection in Rectal Cancer Patients." Turkish Journal of Surgery 36, no. 2 (2020): 224-228.
Harvard	Mahmoodzadeh H et al. (2020) 'Study of Therapeutic Results, Lymph Node Ratio, Short-Term and Long-Term Complications of Lateral Lymph Node Dissection in Rectal Cancer Patients', Turkish Journal of Surgery, 36(2), pp. 224-228.
Vancouver	Mahmoodzadeh H, Omranipour R, Borjian A, Borjian MA. Study of Therapeutic Results, Lymph Node Ratio, Short-Term and Long-Term Complications of Lateral Lymph Node Dissection in Rectal Cancer Patients. Turkish Journal of Surgery. 2020;36(2):224-228.
BibTex	@article{ author = {Mahmoodzadeh H and Omranipour R and Borjian A and Borjian MA}, title = {Study of Therapeutic Results, Lymph Node Ratio, Short-Term and Long-Term Complications of Lateral Lymph Node Dissection in Rectal Cancer Patients}, journal = {Turkish Journal of Surgery}, volume = {36}, number = {2}, pages = {224-228}, year = {2020} }
RIS	TY - JOUR AU - Mahmoodzadeh H AU - Omranipour R AU - Borjian A AU - Borjian MA TI - Study of Therapeutic Results, Lymph Node Ratio, Short-Term and Long-Term Complications of Lateral Lymph Node Dissection in Rectal Cancer Patients JO - Turkish Journal of Surgery VL - 36 IS - 2 SP - 224 EP - 228 PY - 2020 ER -

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