Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Moderate-Intensity Aerobic Exercise on Non-Proliferative Diabetic Retinopathy in Type Ii Diabetes Mellitus Patients: A Clinical Trial Publisher Pubmed



Soleimani A1 ; Soltani P2 ; Karimi H3 ; Mirzaei M4 ; Esfahanian F5 ; Yavari M6 ; Esfahani MP7
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Medicine, Shahid Behesti University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  7. 7. Department of Sports and Exercise Medicine, Shahid Behesti University of Medical Sciences, Tehran, Iran

Source: Microvascular Research Published:2023


Abstract

Introduction: Diabetic retinopathy (DR) is one of the most threatening complications of diabetes and a leading cause of visual loss in working-age population. Although exercise is beneficial in diabetes, previous studies have showed contradictory and inconclusive results on how it effects DR. In this study, we aimed to investigate the effect of moderate-intensity aerobic exercise on non-proliferative diabetic retinopathy. Materials & methods: In this before-after clinical trial, 40 patients with diabetic retinopathy were enrolled by convenient sampling method in Shahid Labbafinejad Hospital in Tehran during 2021–2022. Before the intervention, central macular thickness (CMT, microns) measured by optical coherence tomography (OCT) and fasting blood sugar (FBS, mg/dl) were obtained. Then, patients took part in a 12-week moderate-intensity aerobic exercise (3 sessions per week, each session 45 min). Data were analyzed using SPSS version 26.0. Results: Out of 40 examined patients, 21 (52.5 %) were male and 19 (47.5 %) were female. The mean age of the patients was 50.8 years. The mean rank of FBS (mg/dl) significantly decreased from 21.12 before the exercise to 8.75 after the exercise (p < 0.001). Also, the mean rank of CMT (microns) showed a significant decrease from 21.11 before the intervention to 16.20 after the exercise (p < 0.001). There was a significant positive correlation between patients' age and FBS (mg/dl) before (rho = 0.457, p = 0.003) and after (rho = 0.365, p = 0.021) the intervention. Also, a significant positive correlation was found between patients' age and CMT (microns) before (rho = 0.525, p = 0.001) and after (rho = 0.461, p = 0.003) moderate exercise. Conclusion: Moderate-intensity aerobic exercise leads to lower FBS (mg/dl) and CMT (microns) in patients with diabetic retinopathy, so it may be beneficial for diabetic patients to avoid sedentary lifestyle. © 2023 Elsevier Inc.
Related Docs
1. Dose-Dependent Effect of Supervised Aerobic Exercise on Hba1c in Patients With Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials, Sports Medicine (2022)
2. Iranian National Clinical Practice Guideline for Exercise in Patients With Diabetes, International Journal of Endocrinology and Metabolism (2021)
3. Supervised Group-Exercise Therapy Versus Home-Based Exercise Therapy: Their Effects on Quality of Life and Cardiovascular Risk Factors in Women With Type 2 Diabetes, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2016)
4. Inflammation and Immunological Disarrays Are Associated With Acute Exercise in Type 2 Diabetes, Journal of Diabetes and Metabolic Disorders (2024)
5. Silymarin Reduces Retinal Microvascular Damage in Streptozotocin-Induced Diabetic Rats, Scientific Reports (2022)
Experts (# of related papers)
View all Related Experts
Farideh Razi (1)
Shima Younespour (1)