Osteosarcoma Management in the Precision Medicine Era: Bibliometric Analysis and Clinical Progress (2015–2024) Publisher



Jamshidi K ; Sami SH ; Naghizadeh H ; Shooroki KK ; Ahmadi R ; Khabiri SS
Source: Archives of Bone and Joint Surgery Published:2025

Abstract

Objectives: Osteosarcoma, the most common hi gh-grade mal i gnant bone t umor, has experi enced onl y l i mi ted progress i n therapeuti c opti ons, hi ghl i ghti ng the urgent need f or more effect i ve t reatments. Thi s revi ew exami nes bi bl i ometri c t rends and cl i ni cal devel opments i n ost eosarcoma research f rom 2015 to 2024, wi th a parti cul ar focus on preci si on medi ci ne and personal i zed t herapy. Methods: A search in the Web of Science Core Collection identified 17,476 ost eosarcoma-related publications for bibliometric analysis. Key metrics, including publication trends, international collaborations, and emerging research topics, were evaluated using the Bibliometrix R package. Additionally, a clinical review examined recent innovations in diagnostic imaging, prognostic biomarkers, chemotherapy resistance, targeted therapies, immunotherapies, and surgical techniques. Results: Research publications on osteosarcoma steadily increased, peaking at 2,009 in 2021, with significant contributions from China, the United States, Japan, India, and Italy. Key research themes encompassed apoptosis, metastasis, chemotherapy resistance, and immunotherapy. Advances in imaging techniques, such as dynamic MRI and PET/CT, have significantly enhanced tumor staging and prediction of treatment response. Emerging biomarkers, including genetic alterations (TP53, RB1, MYC) and inflammatory markers, have become important prognostic tools. Surgical innovations, including patient-specific instrumentation and limb-sparing techniques, have improved patient outcomes. Furthermore, targeted therapies (kinase inhibitors, antibody-drug conjugates) and immunotherapies (CAR T-cell therapy, immune checkpoint inhibitors) have demonstrated promising results in clinical trials. Conclusion: Integrating bibliometric insights with clinical advancements underscores the importance of personalized approaches in osteosarcoma management. Predictive imaging biomarkers and precision-targeted therapies play a crucial role, and future research should focus on their clinical validation to enhance patient outcomes. 2025 © BY THE ARCHIVES OF BONE AND JOINT SURGERY.