Decreased Bone Density Induced by Antiepileptic Drugs Can Cause Accelerated Orthodontic Tooth Movement in Male Wistar Rats

Decreased Bone Density Induced by Antiepileptic Drugs Can Cause Accelerated Orthodontic Tooth Movement in Male Wistar Rats Publisher Pubmed

Akhoundi MSA¹ ; Sheikhzadeh S² ; Mirhashemi A³ ; Ansari E³ ; Kheirandish Y⁴ ; Allaedini M¹ ; Dehpour A¹

Show Affiliations

1. Dental Research Center Dentistry Research Institute, Orthodontics Department, Tehran University of Medical Sciences, Tehran, Iran
2. Orthodontics Department, Dental faculty, Babol University of Medical Sciences, Babol, Iran
3. Orthodontics Department, Dental faculty, Tehran University of Medical Sciences, Tehran, Iran
4. Oral and Maxillofacial Radiology Department, Tehran University of Medical Sciences, Tehran, Iran

Source: International Orthodontics Published:2018

Abstract

Purpose: The aim of the present study was to evaluate the effect of the carbamazepine and valproic acid on orthodontic tooth movement in male Wistar rats. Methods: Evaluation of tooth movement after 21 days of drugs infusion was carried out by feeler gauge. Bone densitometry on lateral cephalograms was conducted on days 1 and 21. After dissection of the maxillae, histologic parameters were evaluated. Results: Orthodontic tooth movement was accelerated in experimental groups rather than controls. Optical density was significantly increased in these groups. In histologic sections, mesioapical portion of the PDL (Periodontal Ligament) was wider in experimental groups. Also, distoapical portion of the PDL was wider only in valproic acid group. Conclusion: Valproic acid and carbamazepine can decrease the bone density which may induce the accelerated orthodontic tooth movement in rats. © 2018

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Style	Citing Format
MLA	Akhoundi MSA, et al.. "Decreased Bone Density Induced by Antiepileptic Drugs Can Cause Accelerated Orthodontic Tooth Movement in Male Wistar Rats." International Orthodontics, vol. 16, no. 1, 2018, pp. 73-81.
APA	Akhoundi MSA, Sheikhzadeh S, Mirhashemi A, Ansari E, Kheirandish Y, Allaedini M, Dehpour A (2018). Decreased Bone Density Induced by Antiepileptic Drugs Can Cause Accelerated Orthodontic Tooth Movement in Male Wistar Rats. International Orthodontics, 16(1), 73-81.
Chicago	Akhoundi MSA, Sheikhzadeh S, Mirhashemi A, Ansari E, Kheirandish Y, Allaedini M, Dehpour A. "Decreased Bone Density Induced by Antiepileptic Drugs Can Cause Accelerated Orthodontic Tooth Movement in Male Wistar Rats." International Orthodontics 16, no. 1 (2018): 73-81.
Harvard	Akhoundi MSA et al. (2018) 'Decreased Bone Density Induced by Antiepileptic Drugs Can Cause Accelerated Orthodontic Tooth Movement in Male Wistar Rats', International Orthodontics, 16(1), pp. 73-81.
Vancouver	Akhoundi MSA, Sheikhzadeh S, Mirhashemi A, Ansari E, Kheirandish Y, Allaedini M, et al.. Decreased Bone Density Induced by Antiepileptic Drugs Can Cause Accelerated Orthodontic Tooth Movement in Male Wistar Rats. International Orthodontics. 2018;16(1):73-81.
BibTex	@article{ author = {Akhoundi MSA and Sheikhzadeh S and Mirhashemi A and Ansari E and Kheirandish Y and Allaedini M and Dehpour A}, title = {Decreased Bone Density Induced by Antiepileptic Drugs Can Cause Accelerated Orthodontic Tooth Movement in Male Wistar Rats}, journal = {International Orthodontics}, volume = {16}, number = {1}, pages = {73-81}, year = {2018} }
RIS	TY - JOUR AU - Akhoundi MSA AU - Sheikhzadeh S AU - Mirhashemi A AU - Ansari E AU - Kheirandish Y AU - Allaedini M AU - Dehpour A TI - Decreased Bone Density Induced by Antiepileptic Drugs Can Cause Accelerated Orthodontic Tooth Movement in Male Wistar Rats JO - International Orthodontics VL - 16 IS - 1 SP - 73 EP - 81 PY - 2018 ER -

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