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Epilepsy and Vitamin D: A Comprehensive Review of Current Knowledge Publisher Pubmed



Miratashi Yazdi SA1 ; Abbasi M2 ; Miratashi Yazdi SM3
Authors
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Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Brain Mapping Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, 1333635445, Iran
  3. 3. School of Medicine, Shahed University, Tehran, Iran

Source: Reviews in the Neurosciences Published:2017


Abstract

Vitamin D has been considered as neurosteroid, and its pivotal role in neuroprotection, brain development, and immunomodulation has been noticed in studies; however, our knowledge regarding its role in neurological disorders is still developing. The potential role of vitamin D in the pathophysiology and treatment of epilepsy, as one the most prevalent neurological disorders, has received less attention in recent years. In this article, we review the possible relationship between vitamin D and epilepsy from different aspects, including the action mechanism of vitamin D in the central nervous system and ecological and epidemiological findings. We also present the outcome of studies that evaluated the level of vitamin D and the impact of administrating vitamin D in epileptic patients or animal subjects. We also review the current evidence on interactions between vitamin D and antiepileptic drugs. © 2017 Walter de Gruyter GmbH, Berlin/Boston.
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