White Matter Microstructure Differences in Individuals With Dependence on Cocaine, Methamphetamine, and Nicotine: Findings From the Enigma-Addiction Working Group

White Matter Microstructure Differences in Individuals With Dependence on Cocaine, Methamphetamine, and Nicotine: Findings From the Enigma-Addiction Working Group Publisher Pubmed

Ottinogonzalez J¹ ; Uhlmann A² ; Hahn S¹ ; Cao Z¹ ; Cupertino RB¹ ; Schwab N¹ ; Allgaier N¹ ; Aliaklein N³ ; Ekhtiari H^{4, 5} ; Fouche JP⁶ ; Goldstein RZ³ ; Li CSR⁸ ; Lochner C⁷ ; London ED⁹ Show All Authors

Ottinogonzalez J¹
Uhlmann A²
Hahn S¹
Cao Z¹
Cupertino RB¹
Schwab N¹
Allgaier N¹
Aliaklein N³
Ekhtiari H^{4, 5}
Fouche JP⁶
Goldstein RZ³
Li CSR⁸
Lochner C⁷
London ED⁹
Luijten M¹⁰
Masjoodi S¹¹
Momenan R¹²
Oghabian MA¹¹
Roos A^{7, 13}
Stein DJ¹³
Stein EA¹⁴
Veltman DJ¹⁵
Verdejogarcia A¹⁶
Zhang S⁸
Zhao M¹⁷
Zhong N¹⁷
Jahanshad N¹⁸
Thompson PM¹⁸
Conrod P¹⁹
Mackey S¹
Garavan H¹

Show Affiliations

1. Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, United States
2. Department of Child & Adolescent Psychiatry and Psychotherapy, Technische Universitat Dresden, Dresden, Germany
3. Department of Psychiatry & Neuroscience, Icahn School of Medicine at Mount Sinai, New York City, NY, United States
4. Institute for Cognitive Sciences Studies, University of Tehran, Tehran, Iran
5. Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
6. SA MRC Genomics and Brain Disorders Unit, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa
7. SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa
8. Department of Psychiatry, Yale University, New Haven, CT, United States
9. Department of Psychiatry and Biobehavioural Sciences, University of California, Los Angeles, CA, United States
10. Behavioural Science Institute, Radboud University, Nijmegen, Netherlands
11. Neuroimaging & Analysis Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran
12. Clinical Neuroimaging Research Core, National Institutes on Alcohol Abuse & Alcoholism, National Institutes of Health, Bethesda, MD, United States
13. SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa
14. Neuroimaging Research Branch, Intramural Research Program, National Institute of Drug Abuse, Baltimore, MD, United States
15. Department of Psychiatry, Amsterdam UMC â€“ location VUM, Amsterdam, Netherlands
16. School of Psychological Sciences & Turner Institute for Brain & Mental Health, Monash University, Melbourne, Australia
17. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
18. Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California, San Diego, CA, United States
19. Department of Psychiatry, Universite de Montreal, Montreal, QC, Canada

Source: Drug and Alcohol Dependence Published:2022

Abstract

Background: Nicotine and illicit stimulants are very addictive substances. Although associations between grey matter and dependence on stimulants have been frequently reported, white matter correlates have received less attention. Methods: Eleven international sites ascribed to the ENIGMA-Addiction consortium contributed data from individuals with dependence on cocaine (n = 147), methamphetamine (n = 132) and nicotine (n = 189), as well as non-dependent controls (n = 333). We compared the fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD) of 20 bilateral tracts. Also, we compared the performance of various machine learning algorithms in deriving brain-based classifications on stimulant dependence. Results: The cocaine and methamphetamine groups had lower regional FA and higher RD in several association, commissural, and projection white matter tracts. The methamphetamine dependent group additionally showed lower regional AD. The nicotine group had lower FA and higher RD limited to the anterior limb of the internal capsule. The best performing machine learning algorithm was the support vector machine (SVM). The SVM successfully classified individuals with dependence on cocaine (AUC = 0.70, p < 0.001) and methamphetamine (AUC = 0.71, p < 0.001) relative to non-dependent controls. Classifications related to nicotine dependence proved modest (AUC = 0.62, p = 0.014). Conclusions: Stimulant dependence was related to FA disturbances within tracts consistent with a role in addiction. The multivariate pattern of white matter differences proved sufficient to identify individuals with stimulant dependence, particularly for cocaine and methamphetamine. © 2021

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Style	Citing Format
MLA	Ottinogonzalez J, et al.. "White Matter Microstructure Differences in Individuals With Dependence on Cocaine, Methamphetamine, and Nicotine: Findings From the Enigma-Addiction Working Group." Drug and Alcohol Dependence, vol. 230, no. , 2022, pp. -.
APA	Ottinogonzalez J, Uhlmann A, Hahn S, Cao Z, Cupertino RB, Schwab N, Allgaier N, Aliaklein N, Ekhtiari H, Fouche JP, Goldstein RZ, Li CSR, Lochner C, London ED, Luijten M, Masjoodi S, Momenan R, Oghabian MA, Roos A, ... Garavan H (2022). White Matter Microstructure Differences in Individuals With Dependence on Cocaine, Methamphetamine, and Nicotine: Findings From the Enigma-Addiction Working Group. Drug and Alcohol Dependence, 230(), -.
Chicago	Ottinogonzalez J, Uhlmann A, Hahn S, Cao Z, Cupertino RB, Schwab N, Allgaier N, et al.. "White Matter Microstructure Differences in Individuals With Dependence on Cocaine, Methamphetamine, and Nicotine: Findings From the Enigma-Addiction Working Group." Drug and Alcohol Dependence 230, no. (2022): -.
Harvard	Ottinogonzalez J et al. (2022) 'White Matter Microstructure Differences in Individuals With Dependence on Cocaine, Methamphetamine, and Nicotine: Findings From the Enigma-Addiction Working Group', Drug and Alcohol Dependence, 230(), pp. -.
Vancouver	Ottinogonzalez J, Uhlmann A, Hahn S, Cao Z, Cupertino RB, Schwab N, et al.. White Matter Microstructure Differences in Individuals With Dependence on Cocaine, Methamphetamine, and Nicotine: Findings From the Enigma-Addiction Working Group. Drug and Alcohol Dependence. 2022;230():-.
BibTex	@article{ author = {Ottinogonzalez J and Uhlmann A and Hahn S and Cao Z and Cupertino RB and Schwab N and Allgaier N and Aliaklein N and Ekhtiari H and Fouche JP and Goldstein RZ and Li CSR and Lochner C and London ED and Luijten M and Masjoodi S and Momenan R and Oghabian MA and Roos A and Stein DJ and Stein EA and Veltman DJ and Verdejogarcia A and Zhang S and Zhao M and Zhong N and Jahanshad N and Thompson PM and Conrod P and Mackey S and Garavan H}, title = {White Matter Microstructure Differences in Individuals With Dependence on Cocaine, Methamphetamine, and Nicotine: Findings From the Enigma-Addiction Working Group}, journal = {Drug and Alcohol Dependence}, volume = {230}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Ottinogonzalez J AU - Uhlmann A AU - Hahn S AU - Cao Z AU - Cupertino RB AU - Schwab N AU - Allgaier N AU - Aliaklein N AU - Ekhtiari H AU - Fouche JP AU - Goldstein RZ AU - Li CSR AU - Lochner C AU - London ED AU - Luijten M AU - Masjoodi S AU - Momenan R AU - Oghabian MA AU - Roos A AU - Stein DJ AU - Stein EA AU - Veltman DJ AU - Verdejogarcia A AU - Zhang S AU - Zhao M AU - Zhong N AU - Jahanshad N AU - Thompson PM AU - Conrod P AU - Mackey S AU - Garavan H TI - White Matter Microstructure Differences in Individuals With Dependence on Cocaine, Methamphetamine, and Nicotine: Findings From the Enigma-Addiction Working Group JO - Drug and Alcohol Dependence VL - 230 IS - SP - EP - PY - 2022 ER -

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