Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12]

Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12] Publisher

Bahramsoltani R^{1, 2} ; Shahpiri Z^{1, 2} ; Farzaei MH³ ; Hosseinzadeh L³ ; Rezazadeh D⁴ ; Pourfarzam M⁵ ; Rahimi R^{1, 2}

Show Affiliations

1. Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
3. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
4. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
5. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Published:2023

Abstract

Cinnamon (Cinnamomum verum J. Presl) is a well-known medicinal plant considered as an effective treatment for neurological disorders based on Persian medicine. The aim of the present study was assessing the effect of cinnamon oil, cinnamic acid, and cinnamaldehyde, on the in vitro model of Parkinson's disease (PD). Cinnamon oil, prepared in sesame oil, was phytochemically analyzed using high performance liquid chromatography (HPLC). Pheochromocytoma-12 (PC-12) cells were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as an in vitro model of neurodegeneration in PD. Cell viability, activity of caspase enzymes, and formation of reactive oxygen species (ROS) were evaluated. MPTP significantly decreased cell viability and increased Casp activity, as well as ROS formation. Cinnamon oil and cinnamic acid at 200 μg/mL could significantly reverse MPTP-induced abnormalities in PC-12 cells including Casp activity and ROS formation. Our study supports the beneficial effect of cinnamon oil in neurodegeneration. Further investigations are needed to clarify the mechanisms and main active components. © 2023, MS-Editions. All rights reserved.

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Roja Rahimi (3)

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Style	Citing Format
MLA	Bahramsoltani R, et al.. "Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12]." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, vol. 22, no. 6, 2023, pp. 837-847.
APA	Bahramsoltani R, Shahpiri Z, Farzaei MH, Hosseinzadeh L, Rezazadeh D, Pourfarzam M, Rahimi R (2023). Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12]. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 22(6), 837-847.
Chicago	Bahramsoltani R, Shahpiri Z, Farzaei MH, Hosseinzadeh L, Rezazadeh D, Pourfarzam M, Rahimi R. "Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12]." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 22, no. 6 (2023): 837-847.
Harvard	Bahramsoltani R et al. (2023) 'Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12]', Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 22(6), pp. 837-847.
Vancouver	Bahramsoltani R, Shahpiri Z, Farzaei MH, Hosseinzadeh L, Rezazadeh D, Pourfarzam M, et al.. Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12]. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas. 2023;22(6):837-847.
BibTex	@article{ author = {Bahramsoltani R and Shahpiri Z and Farzaei MH and Hosseinzadeh L and Rezazadeh D and Pourfarzam M and Rahimi R}, title = {Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12]}, journal = {Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas}, volume = {22}, number = {6}, pages = {837-847}, year = {2023} }
RIS	TY - JOUR AU - Bahramsoltani R AU - Shahpiri Z AU - Farzaei MH AU - Hosseinzadeh L AU - Rezazadeh D AU - Pourfarzam M AU - Rahimi R TI - Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12] JO - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas VL - 22 IS - 6 SP - 837 EP - 847 PY - 2023 ER -

Style

Citing Format

MLA

Bahramsoltani R, et al.. "Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12]." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, vol. 22, no. 6, 2023, pp. 837-847.

APA

Bahramsoltani R, Shahpiri Z, Farzaei MH, Hosseinzadeh L, Rezazadeh D, Pourfarzam M, Rahimi R (2023). Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12]. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 22(6), 837-847.

Chicago

Bahramsoltani R, Shahpiri Z, Farzaei MH, Hosseinzadeh L, Rezazadeh D, Pourfarzam M, Rahimi R. "Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12]." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 22, no. 6 (2023): 837-847.

Harvard

Bahramsoltani R et al. (2023) 'Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12]', Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 22(6), pp. 837-847.

Vancouver

Bahramsoltani R, Shahpiri Z, Farzaei MH, Hosseinzadeh L, Rezazadeh D, Pourfarzam M, et al.. Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12]. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas. 2023;22(6):837-847.

BibTex

@article{ author = {Bahramsoltani R and Shahpiri Z and Farzaei MH and Hosseinzadeh L and Rezazadeh D and Pourfarzam M and Rahimi R}, title = {Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12]}, journal = {Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas}, volume = {22}, number = {6}, pages = {837-847}, year = {2023} }

RIS

TY - JOUR
AU - Bahramsoltani R
AU - Shahpiri Z
AU - Farzaei MH
AU - Hosseinzadeh L
AU - Rezazadeh D
AU - Pourfarzam M
AU - Rahimi R
TI - Effects of Cinnamon Oil and Its Main Constituents, Cinnamic Acid and Cinnamaldehyde, on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurodegeneration in Pc-12 Cells; [Efectos Del Aceite De Canela Y Sus Principales Componentes, Acido Cinamico Y Cinamaldehido En La Neurodegeneracion Inducida Por 1-Metil-4-Fenil-1,2,3,6-Tetrahidropiridina En Celulas Pc 12]
JO - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
VL - 22
IS - 6
SP - 837
EP - 847
PY - 2023
ER -

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