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Non-Coding Rnas and Neurodegenerative Diseases: Information of Their Roles in Apoptosis Publisher



Valizadeh M1 ; Derafsh E2 ; Abdi Abyaneh F3 ; Parsamatin SK4 ; Noshabad FZR5 ; Alinaghipour A6 ; Yaghoobi Z7, 8 ; Taheri AT9 ; Dadgostar E10, 11 ; Aschner M12 ; Mirzaei H13 ; Tamtaji OR7, 8 ; Nabavizadeh F7, 8
Authors
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Authors Affiliations
  1. 1. Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Windsor University School of Medicine, Cayon, Canada
  3. 3. School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  4. 4. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Student Research Committee, Kashan University of Medical Sciences, IR, Kashan, Iran
  6. 6. School of Medical Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran
  7. 7. Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, IR, Tehran, Iran
  8. 8. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, IR, Tehran, Iran
  9. 9. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Behavioral Sciences Research Center, Isfahan University of Medical Sciences, IR, Isfahan, Iran
  11. 11. Student Research Committee, Isfahan University of Medical Sciences, IR, Isfahan, Iran
  12. 12. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10461, NY, United States
  13. 13. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, IR, Kashan, Iran

Source: Molecular Neurobiology Published:2023


Abstract

Apoptosis can be known as a key factor in the pathogenesis of neurodegenerative disorders. In disease conditions, the rate of apoptosis expands and tissue damage may become apparent. Recently, the scientific studies of the non-coding RNAs (ncRNAs) has provided new information of the molecular mechanisms that contribute to neurodegenerative disorders. Numerous reports have documented that ncRNAs have important contributions to several biological processes associated with the increase of neurodegenerative disorders. In addition, microRNAs (miRNAs), circular RNAs (circRNAs), as well as, long ncRNAs (lncRNAs) represent ncRNAs subtypes with the usual dysregulation in neurodegenerative disorders. Dysregulating ncRNAs has been associated with inhibiting or stimulating apoptosis in neurodegenerative disorders. Therefore, this review highlighted several ncRNAs linked to apoptosis in neurodegenerative disorders. CircRNAs, lncRNAs, and miRNAs were also illustrated completely regarding the respective signaling pathways of apoptosis. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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