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The Emerging Function of N6-Methyladenosine and Its Regulators in Endometrial Cancer; Current Knowledge and Prospect Publisher



Rabiei M1 ; Ghalandarpoorattar SM2 ; Ghalandarpoorattar SN3 ; Nurzadeh M4
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Authors Affiliations
  1. 1. Obstetrics and Gynecology Department, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Obstetrics and Gynecology Department, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Obstetrics and Gynecology Department, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran
  4. 4. Fetomaternal Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Human Gene Published:2023


Abstract

N6-methyladenosine (m6A) is an epigenetic modification of RNA that was first discovered in mRNA in the 1970s. The principal contributors to RNA methylation modification are methyltransferases, demethylases, and binding proteins. M6A as the most studied RNA modification is crucial to the onset and progression of a wide range of diseases, including malignant tumors. This particular posttranscriptional alteration of RNA is both dynamic and reversible, and it controls several aspects of RNA metabolism in eucaryons such as translation, exporting, splicing, decay, and processing. One of the three most common forms of cancer in women's reproductive organs, endometrial cancer (EC) is a devastating disease. The involvement of m6A regulators in a wide variety of EC activities has been the subject of a large number of investigations. In this study, we focus on the underlying mechanisms of m6A alterations in EC and further discuss the prospective therapeutic targets linked with m6A regulators that might be used in the treatment of cancer. © 2023 Elsevier B.V.
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