Multiple Sclerosis and Air Pollution Exposure: Mechanisms Toward Brain Autoimmunity

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Multiple Sclerosis and Air Pollution Exposure: Mechanisms Toward Brain Autoimmunity Publisher Pubmed

Esmaeil Mousavi S¹ ; Heydarpour P² ; Reis J³ ; Amiri M¹ ; Sahraian MA²

Show Affiliations

1. Social Health Determinants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2. MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Service de Neurologie, Centre Hospitalier Universitaire, Hopital de Hautepierre, 1, avenue Moliere, Strasbourg, 67200, France

Source: Medical Hypotheses Published:2017

Abstract

The association between neurodegenerative diseases and environmental exposures, in particular air pollution, has been noticed in the last two decades, but the importance of this environmental factor in multiple sclerosis (MS) pathogenesis has not been considered extensively. However, recent evidence suggests that major mechanisms involved in MS pathogenesis, such as inflammatory factors expression, free radicals overproduction, the blood brain barrier (BBB) breakdown, neuroinflammation, vitamin D deficiency and mitochondrial dysfunction could also occur due to exposure to air pollutants. A prospective hypothesis is suggested here in which exposure to air pollutants may initiate destructive mechanisms inducing inflammatory-oxidative cascades, reduction of immunological self-tolerance and neurodegeneration leading to brain autoimmunity. © 2017

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Mohammad Ali Sahraian (5)

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Style	Citing Format
MLA	Esmaeil Mousavi S, et al.. "Multiple Sclerosis and Air Pollution Exposure: Mechanisms Toward Brain Autoimmunity." Medical Hypotheses, vol. 100, no. , 2017, pp. 23-30.
APA	Esmaeil Mousavi S, Heydarpour P, Reis J, Amiri M, Sahraian MA (2017). Multiple Sclerosis and Air Pollution Exposure: Mechanisms Toward Brain Autoimmunity. Medical Hypotheses, 100(), 23-30.
Chicago	Esmaeil Mousavi S, Heydarpour P, Reis J, Amiri M, Sahraian MA. "Multiple Sclerosis and Air Pollution Exposure: Mechanisms Toward Brain Autoimmunity." Medical Hypotheses 100, no. (2017): 23-30.
Harvard	Esmaeil Mousavi S et al. (2017) 'Multiple Sclerosis and Air Pollution Exposure: Mechanisms Toward Brain Autoimmunity', Medical Hypotheses, 100(), pp. 23-30.
Vancouver	Esmaeil Mousavi S, Heydarpour P, Reis J, Amiri M, Sahraian MA. Multiple Sclerosis and Air Pollution Exposure: Mechanisms Toward Brain Autoimmunity. Medical Hypotheses. 2017;100():23-30.
BibTex	@article{ author = {Esmaeil Mousavi S and Heydarpour P and Reis J and Amiri M and Sahraian MA}, title = {Multiple Sclerosis and Air Pollution Exposure: Mechanisms Toward Brain Autoimmunity}, journal = {Medical Hypotheses}, volume = {100}, number = {}, pages = {23-30}, year = {2017} }
RIS	TY - JOUR AU - Esmaeil Mousavi S AU - Heydarpour P AU - Reis J AU - Amiri M AU - Sahraian MA TI - Multiple Sclerosis and Air Pollution Exposure: Mechanisms Toward Brain Autoimmunity JO - Medical Hypotheses VL - 100 IS - SP - 23 EP - 30 PY - 2017 ER -

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