The Link Between High Sensitivity Troponin T Levels and Outcomes Among Patients With Congestive Heart Failure: A Systematic Review and Meta-Analysis Study Publisher



A Abdollahi ALIREZA ; Z Nozarian ZOHREH ; S Salarvand SAMANEH ; E Pourebrahimi ELHAM
Source: Iranian Journal of Pathology Published:2025

Abstract

Background & Objective: High-sensitivity cardiac troponin T (hs-cTnT) has emerged as a critical biomarker in cardiovascular diseases, particularly in congestive heart failure (CHF). This systematic review and meta-analysis aimed to assess the association between hs-cTnT levels and clinical outcomes in patients with CHF. Methods: A comprehensive literature search was performed across multiple databases to identify studies evaluating the relationship between hs-cTnT levels and clinical outcomes in CHF. Eligible studies reported hazard ratios (HRs) or odds ratios (ORs) for all-cause mortality, cardiovascular mortality, or cardiovascular hospitalization. Results: Elevated hs-cTnT levels were significantly associated with adverse outcomes. The pooled HR and OR for all-cause mortality were 1.70 (95% CI, 1.49–1.94) and 6.19 (95% CI, 3.88–9.86), respectively. For cardiovascular mortality, the pooled HR was 1.59 (95% CI, 1.38–1.83) and the pooled OR was 6.87 (95% CI, 3.93–12.01). For cardiovascular hospitalization, the pooled HR was 1.56 (95% CI, 1.42–1.70) and the pooled OR was 4.32 (95% CI, 2.22–8.39). Conclusion: Elevated hs-cTnT levels are strongly associated with an increased risk of all-cause mortality, cardiovascular mortality, and cardiovascular hospitalization in patients with CHF. These findings highlight the prognostic value of hs-cTnT in the clinical management of heart failure. © 2025 Elsevier B.V., All rights reserved.