Mechanical Prosthetic Valve Thrombosis: A Literature Review of Treatment Strategies Publisher Pubmed



Ebrahimi P¹ ; Sattartabar B¹ ; Taheri H² ; Soltani P¹ ; Bahiraie P³ ; Mousavinezhad SM⁴ ; Gooshvar M⁴ ; Kampaktsis P⁵ ; Arsanjani R⁶ ; Sahebjam M¹ ; Hosseini K¹ ; Siegel RJ² Show Affiliations
Source: Current Problems in Cardiology Published:2024

Abstract

Mechanical prosthetic valve thrombosis (MPVT) is a common complication of valvular implantations. This study compared the efficacy and safety of different treatments for MPVT. A systematic search of electronic databases identified studies evaluating surgical, anticoagulant, and thrombolytic therapies. Although several studies of different types have been conducted to evaluate the efficacy of these treatment strategies the lack of randomized controlled trials has resulted in the inability to make a definitive conclusion about the pros and cons of these treatments. Recent treatments, such as slow and ultraslow infusion of thrombolytics, showed comparable efficacy and lower complication rates than traditional methods. Inadequate anticoagulant use is a major risk factor for MPVT, highlighting the importance of prevention. Treatment selection should be individualized based on patient factors and available expertise. Overall, slow and ultraslow infusion of thrombolytics may be a promising treatment option for MPVT. © 2024 Elsevier Inc.