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Breast Cancer Immunotherapy: Current and Novel Approaches Publisher Pubmed



Barzaman K1, 2, 6 ; Moradikalbolandi S2 ; Hosseinzadeh A2 ; Kazemi MH1, 3 ; Khorramdelazad H1, 4, 5 ; Safari E1, 6 ; Farahmand L2
Authors
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Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  3. 3. ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  4. 4. Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjani University of Medical Sciences, Rafsanjani, Iran
  5. 5. Department of Immunology, School of Medicine, Rafsanjani University of Medical Sciences, Rafsanjani, Iran
  6. 6. Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: International Immunopharmacology Published:2021


Abstract

The crucial role of the immune system in the progression/regression of breast cancer (BC) should always be taken into account. Various immunotherapy approaches have been investigated for BC, including tumor-targeting antibodies (bispecific antibodies), adoptive T cell therapy, vaccines, and immune checkpoint blockade such as anti-PD-1. In addition, a combination of conventional chemotherapy and immunotherapy approaches contributes to improving patients’ overall survival rates. Although encouraging outcomes have been reported in most clinical trials of immunotherapy, some obstacles should still be resolved in this regard. Recently, personalized immunotherapy has been proposed as a potential complementary medicine with immunotherapy and chemotherapy for overcoming BC. Accordingly, this review discusses the brief association of these methods and future directions in BC immunotherapy. © 2021
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