Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Breast Cancer: Biology, Biomarkers, and Treatments Publisher Pubmed



Barzaman K1, 2 ; Karami J1, 3 ; Zarei Z4 ; Hosseinzadeh A2 ; Kazemi MH5, 6 ; Moradikalbolandi S2 ; Safari E1, 7 ; Farahmand L2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  3. 3. Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biomaterials and Tissue Engineering, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  5. 5. Student Research Committee, Department of Immunology, School of Medicine, Iran University of Medical Science, Tehran, Iran
  6. 6. ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  7. 7. Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: International Immunopharmacology Published:2020


Abstract

During the past recent years, various therapies emerged in the era of breast cancer. Breast cancer is a heterogeneous disease in which genetic and environmental factors are involved. Breast cancer stem cells (BCSCs) are the main player in the aggressiveness of different tumors and also, these cells are the main challenge in cancer treatment. Moreover, the major obstacle to achieve an effective treatment is resistance to therapies. There are various types of treatment for breast cancer (BC) patients. Therefore, in this review, we present the current treatments, novel approaches such as antibody-drug conjugation systems (ADCs), nanoparticles (albumin-, metal-, lipid-, polymer-, micelle-based nanoparticles), and BCSCs-based therapies. Furthermore, prognostic and predictive biomarkers will be discussed also biomarkers that have been applied by some tests such as Oncotype DX, Mamm αPrint, and uPA/PAI-1 are regarded as suitable prognostic and predictive factors in breast cancer. © 2020 Elsevier B.V.
Related Docs
View other Related Docs
1. Tumor Immunology, Clinical Immunology (2022)
2. Functionalised Nanomaterials for Eradication of Cscs, a Promising Approach for Overcoming Tumour Heterogeneity, Journal of Drug Targeting (2018)
3. Chemotherapy: A Double-Edged Sword in Cancer Treatment, Cancer Immunology# Immunotherapy (2022)
4. Breast Cancer Immunotherapy: Current and Novel Approaches, International Immunopharmacology (2021)
5. Applications of Innovation Technologies for Personalized Cancer Medicine: Stem Cells and Gene-Editing Tools, ACS Pharmacology and Translational Science (2023)
6. Glance Into Cancer Stem Cells, Journal of Kerman University of Medical Sciences (2016)
7. Local Immunotherapy of Glioblastoma: A Comprehensive Review of the Concept, Journal of Neuroimmunology (2023)
8. Down-Regulation of Immune Checkpoints by Doxorubicin and Carboplatin-Containing Neoadjuvant Regimens in a Murine Breast Cancer Model, Iranian Journal of Basic Medical Sciences (2021)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (4)
Amir Kasaeian (2)
Other Related Docs
9. Molecular Docking As a Therapeutic Approach for Targeting Cancer Stem Cell Metabolic Processes, Frontiers in Pharmacology (2022)
10. Cancer Stem-Like Cell Behavior in Anaplastic Thyroid Cancer: A Challenging Dilemma, Life Sciences (2016)
11. Upregulation of Circulating Cancer Stem Cell Marker, Dclk1 But Not Lgr5, in Chemoradiotherapy-Treated Colorectal Cancer Patients, Tumor Biology (2015)
12. Stimuli-Responsive Mesoporous Silica Nps As Non-Viral Dual Sirna/Chemotherapy Carriers for Triple Negative Breast Cancer, Molecular Therapy Nucleic Acids (2017)
13. Assessing the Prognostic Factors, Survival, and Recurrence Incidence of Triple Negative Breast Cancer Patients, a Single Center Study in Iran, PLoS ONE (2019)
14. Treatment Outcomes and Clinicopathologic Characteristics of Triple-Negative Breast Cancer: A Report From Cancer Institute of Iran, International Journal of Hematology-Oncology and Stem Cell Research (2017)
15. Expression of Cd133 Cancer Stem Cell Marker in Melanoma: A Systematic Review and Meta-Analysis, International Journal of Biological Markers (2016)
16. Immunopathology and Immunotherapy for Breast Cancer, Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors (2020)
17. Combination Effect of Doxorubicin and Hif Inhibitor on Mcf-7 Cd44+/Cd24-Subpopulation Cells in Hypoxic Condition, Brazilian Journal of Pharmaceutical Sciences (2022)
18. Targeting the Metabolism of Cancer Stem Cells by Energy Disruptor Molecules, Critical Reviews in Oncology/Hematology (2022)
19. Pathological Characteristics of Triple-Negative Breast Cancer at Main Referral Teaching Hospital, April 2014 to April 2015, Tehran, Iran, International Journal of Hematology-Oncology and Stem Cell Research (2016)
20. Clinical Perspective: Antibody-Drug Conjugates for the Treatment of Her2-Positive Breast Cancer, Molecular Therapy (2023)
21. Cancer Nanomedicine: Special Focus on Cancer Immunotherapy, Cancer Immunology: Bench to Bedside Immunotherapy of Cancers# Second Edition (2020)
22. Solid Tumors Challenges and New Insights of Car T Cell Engineering, Stem Cell Reviews and Reports (2019)
23. Applications of Two-Dimensional Nanomaterials in Breast Cancer Theranostics, ACS Biomaterials Science and Engineering (2020)
24. Recent Advances in Regenerative Medicine Strategies for Cancer Treatment, Biomedicine and Pharmacotherapy (2021)
25. Cd44 and Cd74: The Promising Candidates for Molecular Targeted Therapy in Oral Squamous Cell Carcinoma, Dental Research Journal (2015)
26. Epigenetic of Retinoic Acid Receptor ß2 Gene in Breast Cancer, Epigenetics Territory and Cancer (2015)
27. Prospects for Manipulation of Mesenchymal Stem Cells in Tumor Therapy: Anti-Angiogenesis Property on the Spotlight, International Journal of Stem Cells (2021)
28. Autophagy Modulation in Breast Cancer Utilizing Nanomaterials and Nanoparticles, Frontiers in Oncology (2023)
29. Exhaustion of T Lymphocytes in the Tumor Microenvironment: Significance and Effective Mechanisms, Cellular Immunology (2017)
30. Cancer Stem Cell Research in Iran: Potentials and Challenges, Future Oncology (2017)
31. Mechanisms of Tumor Cell Resistance to the Current Targeted-Therapy Agents, Tumor Biology (2016)
32. Approach to the Triple Negative Breast Cancer in New Drugs Area, International Journal of Hematology-Oncology and Stem Cell Research (2016)
33. Tumor-Associated Macrophages and Epithelial–Mesenchymal Transition in Cancer: Nanotechnology Comes Into View, Journal of Cellular Physiology (2018)
34. Lncrnas Roles in Chemoresistance of Cancer Cells, Current Molecular Medicine (2022)
35. Signaling Pathways Governing the Behaviors of Leukemia Stem Cells, Genes and Diseases (2024)
36. The Role of Oncolytic Virotherapy and Viral Oncogenes in the Cancer Stem Cells: A Review of Virus in Cancer Stem Cells, Cancer Cell International (2023)
37. Signaling Crosstalk Between Mesenchymal Stem Cells and Tumor Cells: Implications for Tumor Suppression or Progression, Cytokine and Growth Factor Reviews (2024)
38. Application of Nanotechnology in Targeting of Cancer Stem Cells: A Review, International Journal of Stem Cells (2019)
39. Efficacy and Safety of Immune Checkpoint Inhibitors for Patients With Prostate Cancer: A Systematic Review and Meta-Analysis, Frontiers in Immunology (2023)