Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Phytochemical Investigation and Biological Activity of Doronicum Pardalianches L. Roots Against Alzheimer’S Disease Publisher Pubmed



Manayi A1 ; Rastegari A2 ; Heydarian B3 ; Vahedimazdabadi Y2 ; Khanavi M4 ; Akbarzadeh T2, 3 ; Saeedi M1, 2
Authors

Source: Natural Product Research Published:2023


Abstract

The methanol extract of Doronicum pardalianches L. was fractionated using n-hexane, chloroform, and ethyl acetate to evaluate their cholinesterase (ChE) inhibitory activity via modified Ellman’s method. It was perceived that only the ethyl acetate fraction was active toward acetylcholinesterase (AChE) with IC50 value of 172.21 µg/mL. Also, all fractions showed no butyrylcholinesterase (BChE) inhibitory activity. The ethyl acetate fraction was also investigated for its neuroprotectivity and metal chelating ability (Zn2+, Fe2+, and Cu2+) which demonstrated desired activity. Phytochemical analysis of the ethyl acetate fraction led to isolation and identification of formononetin 7-O-β-D-glucopyranoside which has not been previously reported for this plant. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Cinnamomum Verum J. Presl. Bark Essential Oil: In Vitro Investigation of Anti-Cholinesterase, Anti-Bace1, and Neuroprotective Activity, BMC Complementary Medicine and Therapies (2022)
2. Phytochemical Investigation and Anticholinesterase Activity of Ethyl Acetate Fraction of Myristica Fragrans Houtt. Seeds, Natural Product Research (2020)
3. Oleo-Gum-Resin of Ferula Persica: Phytochemical Analysis and Enzyme Inhibitory Activity Related to Alzheimer’S Disease, Research Journal of Pharmacognosy (2024)
Experts (# of related papers)
View all Related Experts
Mina Saeedi (11)
Tahmineh Akbarzadeh (10)
Other Related Docs
4. Phytochemical Analysis and Evaluation of Biological Activity of Lawsonia Inermis Seeds Related to Alzheimer's Disease, Evidence-based Complementary and Alternative Medicine (2021)
5. Anti-Cholinesterase and Neuroprotective Activities of Sweet and Bitter Apricot Kernels (Prunus Armeniaca L.), Iranian Journal of Pharmaceutical Research (2020)
6. Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo], Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (2021)
7. Design and Synthesis of Novel Arylisoxazole-Chromenone Carboxamides: Investigation of Biological Activities Associated With Alzheimer's Disease, Chemistry and Biodiversity (2020)
8. Dual Functional Cholinesterase and Carbonic Anhydrase Inhibitors for the Treatment of Alzheimer's Disease: Design, Synthesis, in Vitro, and in Silico Evaluations of Coumarin-Dihydropyridine Derivatives, Journal of Molecular Structure (2023)
9. New Imidazo[1,2-A]Pyridin-2-Yl Derivatives As Ache, Bche, and Lox Inhibitors; Design, Synthesis, and Biological Evaluation, Letters in Drug Design and Discovery (2023)
10. Novel Tacrine-Based Acetylcholinesterase Inhibitors As Potential Agents for the Treatment of Alzheimer’S Disease: Quinolotacrine Hybrids, Molecular Diversity (2022)
11. Hetero-Annulated Coumarins As New Ache/Buche Inhibitors: Synthesis and Biological Evaluation, Medicinal Chemistry Research (2016)
12. Design and Synthesis of 2,4-Dioxochroman-Pyridinium-Phenylacetamide Derivatives As New Anti-Alzheimer Agents: In Vitro and in Silico Studies, Journal of the Chinese Chemical Society (2020)
13. Chemical Composition, Cholinesterase, and Α-Glucosidase Inhibitory Activity of the Essential Oils of Some Iranian Native Salvia Species, BMC Complementary Medicine and Therapies (2023)
14. Synthesis and Biological Activity of Some Benzochromenoquinolinones: Tacrine Analogs As Potent Anti-Alzheimer's Agents, Chemistry and Biodiversity (2019)
15. Design, Synthesis, Biological Evaluation, and Molecular Dynamics of Novel Cholinesterase Inhibitors As Anti-Alzheimer's Agents, Archiv der Pharmazie (2019)
16. Design, Synthesis, Molecular Docking, and Cholinesterase Inhibitory Potential of Phthalimide-Dithiocarbamate Hybrids As New Agents for Treatment of Alzheimer's Disease, Chemistry and Biodiversity (2019)
17. Phenyl-Quinoline Derivatives As Lead Structure of Cholinesterase Inhibitors With Potency to Reduce the Gsk-3Β Level Targeting Alzheimer's Disease, International Journal of Biological Macromolecules (2023)
18. Rhodanine-Pyridinium Derivatives As a New Category of Cholinesterase Inhibitors: Design, Synthesis, in Vitro and in Silico Enzymatic Evaluations, International Journal of Biological Macromolecules (2025)
19. Recent Developments in the Design and Synthesis of Benzylpyridinium Salts: Mimicking Donepezil Hydrochloride in the Treatment of Alzheimer’S Disease, Frontiers in Chemistry (2022)
20. Biological Evaluation of the Isolated Compounds From Methanol Fraction of Leutea Avicennia Mozaff, Iranian Journal of Pharmaceutical Research (2018)