Promotion of Cutaneous Diabetic Wound Healing by Subcutaneous Administration of Wharton's Jelly Mesenchymal Stem Cells Derived From Umbilical Cord

Promotion of Cutaneous Diabetic Wound Healing by Subcutaneous Administration of Wharton's Jelly Mesenchymal Stem Cells Derived From Umbilical Cord Publisher Pubmed

Nilforoushzadeh MA^{1, 2} ; Raoofi A³ ; Afzali H¹ ; Gholami O³ ; Zare S¹ ; Nasiry D⁴ ; Khodaverdi Darian E^{5, 6} ; Rustamzadeh A⁷ ; Alavi S¹ ; Ahmadi R⁸ ; Alimohammadi A⁹ ; Razzaghi Z¹⁰ ; Safaie Naraghi Z¹¹ ; Mahmoudbeyk M¹ Show All Authors

Nilforoushzadeh MA^{1, 2}
Raoofi A³
Afzali H¹
Gholami O³
Zare S¹
Nasiry D⁴
Khodaverdi Darian E^{5, 6}
Rustamzadeh A⁷
Alavi S¹
Ahmadi R⁸
Alimohammadi A⁹
Razzaghi Z¹⁰
Safaie Naraghi Z¹¹
Mahmoudbeyk M¹
Amirkhani MA¹
Mousavi Khaneghah A¹²

Show Affiliations

1. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Jordan Dermatology and Hair Transplantation Center, Tehran, Iran
3. Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
4. Amol Faculty of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran
5. Department of Medical Biotechnology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
6. Biotechnology Research Center, Semnan University of Medical Sciences, Semnan, Iran
7. Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
8. Department of Biology, Hamedan Branch, Islamic Azad University, Hamedan, Iran
9. Forensic Medicine Specialist, Research Center of Legal Medicine Organization of Iran, Tehran, Iran
10. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
11. Department of Pathology, Razi Skin Hospital, Tehran University of Medical Sciences, Tehran, Iran
12. Department of Food Science and Nutrition, Faculty of Food Engineering, University of Campinas (UNICAMP), Rua Monteiro Lobato, 80, Caixa Postal: 6121, Sao Paulo, Campinas, CEP: 13083-862, Brazil

Source: Archives of Dermatological Research Published:2023

Abstract

Wound healing is a major problem in diabetic patients, and current treatments have been confronted with limited success. The present study examined the benefit of Wharton's jelly mesenchymal stem cells (WJ-MSCs) derived from the human umbilical cord (UC) in wound healing in diabetic rats. Thirty days after inducing diabetes, a circular excision was created in the skin of rats, and the treatments were performed for 21 days. Two groups were studied, which included the Control group and WJ-MSCs group. The studied groups were sampled on the 7th, 14th, and 21st days after wounding. Histological ultrasound imaging of dermis and epidermis in the wound area for thickness and density measurement and skin elasticity were evaluated. Our results on post-wounding days 7, 14, and 21 showed that the wound closure, thickness, and density of new epidermis and dermis, as well as skin elasticity in the healed wound, were significantly higher in the WJ-MSCs group compared to the Control group. Subcutaneous administration of WJ-MSCs in diabetic wounds can effectively accelerate healing. Based on this, these cells can be used along with other treatment methods in the healing of different types of chronic wounds. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

2. Topical Spray of Wharton's Jelly Mesenchymal Stem Cells Derived From Umbilical Cord Accelerates Diabetic Wound Healing, Journal of Cosmetic Dermatology (2022)

3. Diabetic Ulcer Regeneration: Stem Cells, Biomaterials, Growth Factors, Artificial Cells# Nanomedicine and Biotechnology (2018)

4. Evaluation of the Effect of an Intradermal Injection of Wharton's Jelly-Derived Mesenchymal Stem Cells in Diabetic Wound Healing in Animal Model, Tehran University Medical Journal (2021)

5. Can Regenerative Medicine and Nanotechnology Combine to Heal Wounds? the Search for the Ideal Wound Dressing, Nanomedicine (2017)

6. Elevating Dermatology Beyond Aesthetics: Perinatal-Derived Advancements for Rejuvenation, Alopecia Strategies, Scar Therapies, and Progressive Wound Healing, Stem Cell Reviews and Reports (2025)

7. Medicinal Plants As Efficacious Agents for Diabetic Foot Ulcers: A Systematic Review of Clinical Studies, Wounds (2021)

8. Alterations in Apoptotic Pathways and Expression of Mir-134, Mir-181, and Mir-497 Induced by Wharton's Jelly-Derived Mesenchymal Stem Cells in a Rat Model of Ischemic Brain Injury, IBRO Neuroscience Reports (2025)

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Mohammad Ali Nilforoushzadeh (4)

Roja Rahimi (1)

Style	Citing Format
MLA	Nilforoushzadeh MA, et al.. "Promotion of Cutaneous Diabetic Wound Healing by Subcutaneous Administration of Wharton's Jelly Mesenchymal Stem Cells Derived From Umbilical Cord." Archives of Dermatological Research, vol. 315, no. 2, 2023, pp. 147-159.
APA	Nilforoushzadeh MA, Raoofi A, Afzali H, Gholami O, Zare S, Nasiry D, Khodaverdi Darian E, Rustamzadeh A, Alavi S, Ahmadi R, Alimohammadi A, Razzaghi Z, Safaie Naraghi Z, Mahmoudbeyk M, Amirkhani MA, Mousavi Khaneghah A (2023). Promotion of Cutaneous Diabetic Wound Healing by Subcutaneous Administration of Wharton's Jelly Mesenchymal Stem Cells Derived From Umbilical Cord. Archives of Dermatological Research, 315(2), 147-159.
Chicago	Nilforoushzadeh MA, Raoofi A, Afzali H, Gholami O, Zare S, Nasiry D, Khodaverdi Darian E, et al.. "Promotion of Cutaneous Diabetic Wound Healing by Subcutaneous Administration of Wharton's Jelly Mesenchymal Stem Cells Derived From Umbilical Cord." Archives of Dermatological Research 315, no. 2 (2023): 147-159.
Harvard	Nilforoushzadeh MA et al. (2023) 'Promotion of Cutaneous Diabetic Wound Healing by Subcutaneous Administration of Wharton's Jelly Mesenchymal Stem Cells Derived From Umbilical Cord', Archives of Dermatological Research, 315(2), pp. 147-159.
Vancouver	Nilforoushzadeh MA, Raoofi A, Afzali H, Gholami O, Zare S, Nasiry D, et al.. Promotion of Cutaneous Diabetic Wound Healing by Subcutaneous Administration of Wharton's Jelly Mesenchymal Stem Cells Derived From Umbilical Cord. Archives of Dermatological Research. 2023;315(2):147-159.
BibTex	@article{ author = {Nilforoushzadeh MA and Raoofi A and Afzali H and Gholami O and Zare S and Nasiry D and Khodaverdi Darian E and Rustamzadeh A and Alavi S and Ahmadi R and Alimohammadi A and Razzaghi Z and Safaie Naraghi Z and Mahmoudbeyk M and Amirkhani MA and Mousavi Khaneghah A}, title = {Promotion of Cutaneous Diabetic Wound Healing by Subcutaneous Administration of Wharton's Jelly Mesenchymal Stem Cells Derived From Umbilical Cord}, journal = {Archives of Dermatological Research}, volume = {315}, number = {2}, pages = {147-159}, year = {2023} }
RIS	TY - JOUR AU - Nilforoushzadeh MA AU - Raoofi A AU - Afzali H AU - Gholami O AU - Zare S AU - Nasiry D AU - Khodaverdi Darian E AU - Rustamzadeh A AU - Alavi S AU - Ahmadi R AU - Alimohammadi A AU - Razzaghi Z AU - Safaie Naraghi Z AU - Mahmoudbeyk M AU - Amirkhani MA AU - Mousavi Khaneghah A TI - Promotion of Cutaneous Diabetic Wound Healing by Subcutaneous Administration of Wharton's Jelly Mesenchymal Stem Cells Derived From Umbilical Cord JO - Archives of Dermatological Research VL - 315 IS - 2 SP - 147 EP - 159 PY - 2023 ER -

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