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Can Regenerative Medicine and Nanotechnology Combine to Heal Wounds? the Search for the Ideal Wound Dressing Publisher Pubmed



Zarrintaj P1 ; Moghaddam AS1 ; Manouchehri S1 ; Atoufi Z1 ; Amiri A1 ; Amirkhani MA2 ; Nilforoushzadeh MA2 ; Saeb MR3 ; Hamblin MR4, 5, 6 ; Mozafari M7, 8, 9
Authors
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Authors Affiliations
  1. 1. School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
  2. 2. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Resin and Additives, Institute for Color Science and Technology, P.O. Box 1765-654, Tehran, Iran
  4. 4. Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, 02114, MA, United States
  5. 5. Department of Dermatology, Harvard Medical School, Boston, 02115, MA, United States
  6. 6. Harvard-MIT Division of Health Sciences and Technology, Cambridge, 02139, MA, United States
  7. 7. Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran
  8. 8. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Nanomedicine Published:2017


Abstract

Skin is the outermost covering of the human body and at the same time the largest organ comprising 15% of body weight and 2 m2 surface area. Skin plays a key role as a barrier against the outer environment depending on its thickness, color and structure, which differ from one site to another. The four major types of problematic wounds include ulcers (diabetic, venous, pressure) and burn wounds. Developing novel dressings helps us to improve the wound healing process in difficult patients. Recent advances in regenerative medicine and nanotechnology are revolutionizing the field of wound healing. Antimicrobial activity, exogenous cell therapy, growth factor delivery, biodegradable and biocompatible matrix construction, all play a role in hi-tech dressing design. In the present review, we discuss how the principles of regenerative medicine and nanotechnology can be combined in innovative wound dressings. © 2017 Future Medicine Ltd.
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