Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Naringenin Improves Learning and Memory in an Alzheimer's Disease Rat Model: Insights Into the Underlying Mechanisms Publisher Pubmed



Ghofrani S1, 2 ; Joghataei MT2 ; Mohseni S1 ; Baluchnejadmojarad T4 ; Bagheri M1, 3 ; Khamse S5 ; Roghani M6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical and Experimental Medicine, Faculty of Medicine and Health Sciences, Linkoping University, Linkoping, Sweden
  2. 2. Department of Neuroscience, School of Advanced Technology, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Physiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran
  4. 4. Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Neurophysiology Research Center, Shahed University, Tehran, Iran

Source: European Journal of Pharmacology Published:2015


Abstract

Alzheimer's disease (AD) is one of the prevalent neurological disorders of the central nervous system hallmarked by increased beta-amyloid (Aβ) deposition and ensuing learning and memory deficit. In the present study, the beneficial effect of naringenin on improvement of learning and memory was evaluated in an Alzheimer's disease rat model. The Aβ-injected rats showed a lower alternation score in Y-maze task, impairment of retention and recall capability in passive avoidance test, and lower correct choices and higher errors in radial arm maze (RAM) task as compared to sham group in addition to enhanced oxidative stress and apoptosis. Naringenin, but not a combination of naringenin and fulvestrant (an estrogenic receptor antagonist) significantly improved the performance of Aβ-injected rats in passive avoidance and RAM tasks. Naringenin pretreatment of Aβ-injected rats also lowered hippocampal malondialdehyde (MDA) with no significant effect on nitrite and superoxide dismutase (SOD) activity in addition to lowering apoptosis. These results suggest naringenin pretreatment attenuates Aβ-induced impairment of learning and memory through mitigation of lipid peroxidation and apoptosis and its beneficial effect is somewhat mediated via estrogenic pathway. © 2015 Elsevier B.V. All rights reserved.
Related Docs
View other Related Docs
1. Satureja Bachtiarica Ameliorate Beta-Amyloid Induced Memory Impairment, Oxidative Stress and Cholinergic Deficit in Animal Model of Alzheimer’S Disease, Metabolic Brain Disease (2016)
2. Pelargonidin Improves Memory Deficit in Amyloid Β25-35 Rat Model of Alzheimer's Disease by Inhibition of Glial Activation, Cholinesterase, and Oxidative Stress, Biomedicine and Pharmacotherapy (2016)
3. Molecular and Therapeutic Targets of Genistein in Alzheimer’S Disease, Molecular Neurobiology (2017)
4. Rosmarinic Acid Exerts a Neuroprotective Effect in the Kainate Rat Model of Temporal Lobe Epilepsy: Underlying Mechanisms, Pharmaceutical Biology (2015)
5. Ferulic Acid Attenuates Kainate-Induced Neurodegeneration in a Rat Poststatus Epilepticus Model, Current Molecular Pharmacology (2023)
6. Sesamin Imparts Neuroprotection Against Intrastriatal 6-Hydroxydopamine Toxicity by Inhibition of Astroglial Activation, Apoptosis, and Oxidative Stress, Biomedicine and Pharmacotherapy (2017)
7. Neuroprotective Effect of New Nanochelating-Based Nano Complex, Alzc3, Against Aβ (1–42)-Induced Toxicity in Rat: A Comparison With Memantine, Pharmaceutical Research (2020)
8. Injection of Insulin Amyloid Fibrils in the Hippocampus of Male Wistar Rats: Report on Memory Impairment and Formation of Amyloid Plaques, Neurological Sciences (2015)
Experts (# of related papers)
View all Related Experts
Mohammad Sharifzadeh (10)
Fatemeh Atyabi (4)
Other Related Docs
9. A Comprehensive Systematic Review of the Effects of Naringenin, a Citrus-Derived Flavonoid, on Risk Factors for Nonalcoholic Fatty Liver Disease, Advances in Nutrition (2021)
10. Assessment of Lipophilic Fluorescence Products in Β-Amyloid-Induced Cognitive Decline: A Parallel Track in Hippocampus, Csf, Plasma and Erythrocytes, Experimental Gerontology (2022)
11. Total Scale Analysis of Organic Acids and Their Role to Mitigate Alzheimer's Disease, South African Journal of Botany (2022)
12. Key Mechanisms Underlying Netrin-1 Prevention of Impaired Spatial and Object Memory in Aβ1-42 Ca1-Injected Rats, Clinical and Experimental Pharmacology and Physiology (2019)
13. How Sodium Arsenite Improve Amyloid Β-Induced Memory Deficit?, Physiology and Behavior (2016)
14. Ferulic Acid-Loaded Nanostructured Lipid Carriers: A Promising Nanoformulation Against the Ischemic Neural Injuries, Life Sciences (2018)
15. Naringenin: A Potential Flavonoid Phytochemical for Cancer Therapy, Life Sciences (2022)
16. Effects of Quercetin Against Fluoride-Induced Neurotoxicity in the Medial Prefrontal Cortex of Rats: A Stereological, Histochemical and Behavioral Study, Food and Chemical Toxicology (2025)
17. Autism-Like Symptoms by Exposure to Air Pollution and Valproic Acid–Induced in Male Rats, Environmental Science and Pollution Research (2022)
18. Ameliorating of Memory Impairment and Apoptosis in Amyloid Β-Injected Rats Via Inhibition of Nitric Oxide Synthase: Possible Participation of Autophagy, Iranian Journal of Pharmaceutical Research (2015)
19. The 40-Hz White Light-Emitting Diode (Led) Improves the Structure–Function of the Brain Mitochondrial Katp Channel and Respiratory Chain Activities in Amyloid Beta Toxicity, Molecular Neurobiology (2022)
20. Sericin Alleviates Motor Dysfunction by Modulating Inflammation and Trkb/Bdnf Signaling Pathway in the Rotenone-Induced Parkinson’S Disease Model, BMC Pharmacology and Toxicology (2023)
21. Pharmacotherapeutic Potential of Soy Isoflavones in Neurological Disorders, Neurology Asia (2022)
22. Protective Effects of Salicylate on Pka Inhibitor (H-89)-Induced Spatial Memory Deficit Via Lessening Autophagy and Apoptosis in Rats, Pharmacology Biochemistry and Behavior (2016)
23. A Camp Analog Attenuates Beta-Amyloid (1–42)-Induced Mitochondrial Dysfunction and Spatial Learning and Memory Deficits, Brain Research Bulletin (2018)
24. Aerobic Training With Naringin Supplementation Improved Spatial Cognition Via H2s Signaling Pathway in Alzheimer’S Disease Model Rats, Experimental Aging Research (2023)
25. Synthesis, Docking, Pharmacokinetic Prediction, and Acetylcholinesterase Inhibitory Evaluation of N-(2-(Piperidine-1-Yl)Ethyl)Benzamide Derivatives As Potential Anti-Alzheimer Agents, Research in Pharmaceutical Sciences (2024)
26. Impact of Green-Synthesized Silver Nanoparticles on Cognitive Function and Fluorescence Spectroscopy of Redox Status in the Hippocampus, Nanomedicine Research Journal (2022)
27. Melatonin Reverses H-89 Induced Spatial Memory Deficit: Involvement of Oxidative Stress and Mitochondrial Function, Behavioural Brain Research (2017)
28. Evaluation of Hippocampal Arylalkylamine N-Acetyltransferase Activity in Amyloid-Β Neurotoxicity, Journal of Molecular Endocrinology (2023)
29. Application of Nanostructured Lipid Carriers: The Prolonged Protective Effects for Sesamol in in Vitro and in Vivo Models of Ischemic Stroke Via Activation of Pi3k Signalling Pathway, DARU# Journal of Pharmaceutical Sciences (2017)
30. Effects of Mercuric Chloride on Spatial Memory Deficit-Induced by Beta-Amyloid and Evaluation of Mitochondrial Function Markers in the Hippocampus of Rats, Metallomics (2020)
31. Protective Effects of Flavonoids Against Alzheimer's Disease-Related Neural Dysfunctions, Biomedicine and Pharmacotherapy (2017)
32. Bucladesine Attenuates Spatial Learning and Hippocampal Mitochondrial Impairments Induced by 3, 4-Methylenedioxymethamphetamine (Mdma), Neurotoxicity Research (2020)
33. Pre- and Post-Treatment of Α-Tocopherol on Cognitive, Synaptic Plasticity, and Mitochondrial Disorders of the Hippocampus in Icv-Streptozotocin-Induced Sporadic Alzheimer’S-Like Disease in Male Wistar Rat, Frontiers in Neuroscience (2023)
34. Paeonol Protection Against Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease, Basic and Clinical Neuroscience (2021)
35. Geldanamycin Reduces Aβ-Associated Anxiety and Depression, Concurrent With Autophagy Provocation, Journal of Molecular Neuroscience (2015)
36. Reduction of Autophagy Markers Mediated Protective Effects of Jnk Inhibitor and Bucladesine on Memory Deficit Induced by Aβ in Rats, Naunyn-Schmiedeberg's Archives of Pharmacology (2016)
37. Ferulic Acid, a Phenolic Compound With Therapeutic Effects in Neuropsychiatric Disorders, Stimulates the Production of Nerve Growth Factor and Endocannabinoids in Rat Brain, Physiology and Pharmacology (Iran) (2017)
38. Huperzine a Ameliorates Cognitive Dysfunction and Neuroinflammation in Kainic Acid-Induced Epileptic Rats by Antioxidant Activity and Nlrp3/Caspase-1 Pathway Inhibition, Clinical and Experimental Pharmacology and Physiology (2019)
39. The Endocannabinoid System and Ngf Are Involved in the Mechanism of Action of Resveratrol: A Multi-Target Nutraceutical With Therapeutic Potential in Neuropsychiatric Disorders, Psychopharmacology (2016)
40. Brain Region Specificity of Mitochondrial Biogenesis and Bioenergetics Response to Nrf2 Knockdown: A Comparison Among Hippocampus, Prefrontal Cortex and Amygdala of Male Rat Brain, Brazilian Archives of Biology and Technology (2017)
41. Lactobacilli and Bifidobacteria Ameliorate Memory and Learning Deficits and Oxidative Stress in Β-Amyloid (1–42) Injected Rats, Applied Physiology# Nutrition and Metabolism (2018)