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Covid-19 Vaccination in Patients With Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to Covid-19: A Usidnet Report Publisher Pubmed



Mcdonnell J1 ; Cousins K2 ; Younger MEM3 ; Lane A4, 5 ; Abolhassani H6, 7 ; Abraham RS8, 9 ; Altamemi S10 ; Aldavebecerra JC11 ; Alfaris EH12 ; Alfaromurillo A13 ; Alkhater SA14, 15 ; Alsaati N16 ; Doss AMA17 ; Anderson M18 Show All Authors
Authors
  1. Mcdonnell J1
  2. Cousins K2
  3. Younger MEM3
  4. Lane A4, 5
  5. Abolhassani H6, 7
  6. Abraham RS8, 9
  7. Altamemi S10
  8. Aldavebecerra JC11
  9. Alfaris EH12
  10. Alfaromurillo A13
  11. Alkhater SA14, 15
  12. Alsaati N16
  13. Doss AMA17
  14. Anderson M18
  15. Angarola E19
  16. Ariue B20
  17. Arnold DE21
  18. Assaad AH22
  19. Aytekin C23
  20. Bank M24
  21. Bergerson JRE25
  22. Bleesing J4, 5
  23. Boesing J26
  24. Bouso C27
  25. Brodszki N28
  26. Cabanillas D29
  27. Cady C30
  28. Callahan MA31
  29. Caorsi R32
  30. Carbone J33
  31. Carrabba M34
  32. Castagnoli R35, 36
  33. Catanzaro JR37
  34. Chan S38
  35. Chandra S4, 5
  36. Chapdelaine H39
  37. Chavoshzadeh Z40
  38. Chong HJ41
  39. Connors L42
  40. Consonni F43
  41. Correajimenez O44
  42. Cunninghamrundles C2
  43. Dastousgauthier K45
  44. Delmonte OM25
  45. Demirdag YY46
  46. Deshpande DR47
  47. Diazcabrera NM48
  48. Dimitriades VR49
  49. Elowaidy R50
  50. Elghazali G51
  51. Alhammadi S52
  52. Fabio G34
  53. Faure AS53
  54. Feng J54
  55. Fernandez JM55
  56. Fill L56
  57. Franco GR57
  58. Frenck RW5, 58
  59. Fuleihan RL59
  60. Giardino G60
  61. Galantswafford J61
  62. Gambineri E43, 62
  63. Garabedian EK63
  64. Geerlinks AV64
  65. Goudouris E65
  66. Grecco O57
  67. Panhammarstrom Q6
  68. Khani HHK40
  69. Hammarstrom L6
  70. Hartog NL66
  71. Heimall J67
  72. Hernandezmolina G68
  73. Horner CC69
  74. Hostoffer RW56
  75. Hristova N70
  76. Hsiao KC71, 72, 73
  77. Ivankovichescoto G74
  78. Jaber F54
  79. Jalil M75
  80. Jamee M76
  81. Jean T46
  82. Jeong S54
  83. Jhaveri D77
  84. Jordan MB4, 5, 78
  85. Joshi AY79
  86. Kalkat A56
  87. Kanarek HJ80
  88. Kellner ES81
  89. Khojah A82
  90. Khoury R4, 5
  91. Kokron CM57
  92. Kumar A4, 5
  93. Lecerf K83
  94. Lehman HK84
  95. Leiding JW85
  96. Lesmana H86
  97. Lim XR87
  98. Lopes JP88
  99. Lopez AL89
  100. Tarquini L90
  101. Lundgren IS91
  102. Magnusson J92
  103. Marinho AKBB57
  104. Marseglia GL35
  105. Martone GM84
  106. Mechtler AG93
  107. Mendonca L57, 94
  108. Milner JD95
  109. Mustillo PJ96
  110. Naderi AG97
  111. Naviglio S98
  112. Nell J99
  113. Niebur HB100
  114. Notarangelo L25
  115. Oleastro M27
  116. Ortegalopez MC101
  117. Patel NR102
  118. Petrovic G103
  119. Pignata C104
  120. Porras O105
  121. Prince BT96
  122. Puck JM106
  123. Qamar N107
  124. Rabusin M98
  125. Raje N18
  126. Regairaz L108
  127. Risma KA109
  128. Ristagno EH110
  129. Routes J111
  130. Roxojunior P112
  131. Salemi N113
  132. Scalchunes C114
  133. Schuval SJ115
  134. Seneviratne SL116
  135. Shankar A56
  136. Sherkat R113
  137. Shin JJ117
  138. Siddiqi A118
  139. Signa S32
  140. Sobh A119
  141. Lima FMS57
  142. Stenehjem KK102
  143. Tam JS120
  144. Tang M121
  145. Barros MT57
  146. Verbsky J111
  147. Vergadi E122
  148. Voelker DH123
  149. Volpi S32, 124
  150. Wall LA125
  151. Wang C126
  152. Williams KW127
  153. Wu EY128
  154. Wu SS129, 130
  155. Zhou JJ131
  156. Cook A111
  157. Sullivan KE16
  158. Marsh R4, 5

Source: Journal of clinical immunology Published:2024


Abstract

BACKGROUND: The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI. OBJECTIVE: To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI. METHODS: We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022. RESULTS: Physicians entered data on 1245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least one COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication, and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p < 0.001), ICU admission (2.8% versus 7.6%, p = 0.013), and death (2.3% versus 4.3%, p = 0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission. CONCLUSION: Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity. © 2024. The Author(s).
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