Transplantation of Autologous Fat, Stromal Vascular Fraction (Svf) Cell, and Platelet-Rich Plasma (Prp) for Cell Therapy of Atrophic Acne Scars: Clinical Evaluation and Biometric Assessment Publisher Pubmed



Nilforoushzadeh MA^{1, 2} ; Heidarikharaji M^{1, 2} ; Alavi S¹ ; Nouri M¹ ; Nikkhah N¹ ; Jahangiri F¹ ; Mahmoudbeyk M¹ ; Peyrovan A¹ ; Baiat Tork B¹ ; Torkamaniha E^{1, 2} ; Zare S¹ Show Affiliations
Source: Journal of Cosmetic Dermatology Published:2022

Abstract

Background: Scarring is an unfortunate result of acne because it causes the psychological and cosmetic problems for the patients. Unfortunately, no single treatment is suitable, and using multiple methods may have a better result. The autologous fat and stromal vascular fraction (SVF) cells and their secretory factors can enhance the angiogenesis, collagen synthesis, and migration of fibroblasts, therefore regenerate hurt tissues. Moreover, other treatments for acne scarring, such as platelet-rich plasma (PRP), induce the increase in scare. Aims: This study aimed to verify the effectiveness of transplantation of autologous fat, SVF cells, and PRP as cell therapy techniques on atrophic acne scars. Patients/Methods: This study included 9 adult patients with atrophic acne scars on face. All patients received the transplantation of autologous fat, stromal vascular fraction (SVF) cells, and PRP. The treatment outcome was measured by biometric assessment (VisioFace 1000 D, Colorimeter, multi-probe adapter Cutometer, Tewameter, Mexameter, and skin ultrasound imaging system), and also, the satisfaction of patients was evaluated. The patients were followed 6 months after the treatment. Results: There was a significant improvement in the skin pores, spots, skin lightness and melanin content of skin, skin elasticity, and TEWL (transepidermal water loss) after 6 months of the treatment. Furthermore, denser skin layers were observed both in the epidermis and in the dermis. Moreover, 66.6% of patients showed good satisfaction after the treatment. Conclusion: In brief, the transplantation of autologous fat, SVF cells, and PRP is an effective cell therapy for atrophic acne scars. © 2021 Wiley Periodicals LLC.