Stem Cells and Targeted Gene Therapy in Brain and Spinal Cord Tumors Publisher Pubmed



Pourrashidi A¹ ; Mohammadi E² ; Rezaei N^{3, 5} ; Hanaei S^{4, 5} Show Affiliations
Source: Advances in Experimental Medicine and Biology Published:2023

Abstract

The CNS tumors, in particular those with malignant characteristics, are prominent burdens around the world with high mortality and low cure rate. Given that, researchers were curious about novel treatments with promising effectiveness which resulted in shifting the dogmatism era of neurogenesis to the current concept of postnatal neurogenesis. Considering all existing stem cells, various strategies are available for treating CNS cancers, including hematopoietic stem cells transplantation, mesenchymal stem cells transplantation, neural stem cells (NSCs) transplantation, and using stem cells as genetic carriers called “suicide gene therapy”. Despite some complications, this ongoing therapeutic method has succeeded in decreasing tumor volume, inhibiting tumor progression, and enhancing patients’ survival. These approaches could lead to acceptable results, relatively better safety, and tolerable side effects compared to conventional chemo and radiotherapy. Accordingly, this treatment will be applicable to a wide range of CNS tumors in the near future. Furthermore, tumor genomic analysis and understanding of the underlying molecular mechanisms will help researchers determine patient selection criteria for targeted gene therapy. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.