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Quercetin and Glioma: Which Signaling Pathways Are Involved? Publisher Pubmed



Tamtaji OR1, 6 ; Razavi ZS2 ; Razzaghi N3 ; Aschner M4 ; Barati E5 ; Mirzaei H1
Authors
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Authors Affiliations
  1. 1. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Laboratory Sciences Research Centre, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
  4. 4. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10461, NY, United States
  5. 5. Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran
  6. 6. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Current Molecular Pharmacology Published:2022


Abstract

Gliomas are the most common brain tumors. These tumors commonly exhibit continuous growth without invading surrounding brain tissues. Dominant remedial approaches suffer limited therapy and survival rates. Although some progress has been made in conventional glioma treatments, these breakthroughs have not yet proven sufficient for treating this malignancy. The remedial options are limited given gliomas' aggressive metastasis and drug resistance. Quercetin, a flavonoid, is an anti-oxidative, anti-allergic, antiviral, anti-inflammatory, and anticancer compound. Multiple lines of evidence have shown that Quercetin has anti-tumor effects, documenting this natural compound exerts its pharmacological effects by targeting a variety of cellular and molecular processes, i.e., apoptosis, metastasis, and autophagy. Herein, we summarize various cellular and molecular pathways that are affected by Quercetin in gliomas. © 2022 Bentham Science Publishers.