18F-Fdg Micropet and Mri Targeting Breast Cancer Mouse Model With Designed Synthesis Nanoparticles Publisher



Rezaei Aghdam H¹ ; Bitarafan Rajabi A² ; Sadat Ebrahimi SE³ ; Beiki D⁴ ; Abdi K¹ ; Mousavi Motlagh SS⁵ ; Kiani Dehkordi B⁶ ; Darbandi Azar A² ; Shafiee Ardestani M¹ Show Affiliations
Source: Journal of Nanomaterials Published:2022

Abstract

The first aim of this study was the development of real-time, quantitative, and noninvasive visual observation that necessitates different noninvasive multimodal imaging methods. Second, the design of a high-sensitivity imaging free-ligand green chemistry nanoprobe is a critical diagnosis of breast cancer mouse models. The gadolinium-based nanoparticles as box-Behnken design (BBD) experiment are synthesized. A small biomolecule L-glutamine is attached to its surface nanoparticles as a template. Large surface-area-to-volume ratios of nanoparticles enhance the capacity for interactions with biomolecules and present more sites for conjugation. G. 2-Deoxy-2[18F]fluoro-D-glucose ([18F]F-FDG) is a quantitative and sensitive tracking instrument in Positron Emission Tomography (PET), also applicable for the in vivo and in vitro characterization of L-glutamine SiGdNPs. Optical imaging was done for 4T1 breast cancer tumor-induced mice. 18F-NP uptake values were significantly higher in primary breast cancer and brain tumors than [18F]F-FDG in PET at 30 min, injected (20 μl/g) via the tail vein with about 300 μCi of 18F-FDG loading. After 15 min of the administration of injection (26 μl/g), the first passed the lung intravenously without any injury to the lung showing promising T1-T2 MRI contrast properties. We receive these by application of a variety of imaging modalities, especially microPET and MRI. © 2022 Hakimeh Rezaei Aghdam et al.