Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent

Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent Publisher

Almasi T¹ ; Gholipour N^{2, 3} ; Akhlaghi M⁴ ; Mokhtari Kheirabadi A⁴ ; Mazidi SM⁵ ; Hosseini SH⁶ ; Geramifar P⁴ ; Beiki D⁴ ; Rostampour N¹ ; Shahbazi Gahrouei D⁷

Show Affiliations

1. Department of Radiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
2. Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
3. Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
4. Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
6. Department of Chemical Engineering, University of Science and Technology of Mazandaran, Behshahr, Iran
7. Department of Medical Physics, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2021

Abstract

Gallium-68 radiolabeled DOTA- acetyl-PAMAM coated iron oxide nanoparticles (NPs) were developed as dual-modality agents for PET-MR imaging. The increase in the chelator content, acetylation step, and radiolabeling condition had distinctive effects on the physical, biological, and radiochemical properties of NPs. The r2 relaxivity coefficient value of the NPs was 96.7 mM−1s−1. High accumulation of candidate NPs was in the liver and spleen and about 3.4% ID/g uptake (tissue sampling), and a distinctive uptake (PET-CT image) were observed in the tumor site. These NPs could be used as the dual-modality agent for the diagnosis of the tumors via PET-MR imaging. © 2020 Taylor & Francis Group, LLC.

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Style	Citing Format
MLA	Almasi T, et al.. "Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent." International Journal of Polymeric Materials and Polymeric Biomaterials, vol. 70, no. 15, 2021, pp. 1077-1089.
APA	Almasi T, Gholipour N, Akhlaghi M, Mokhtari Kheirabadi A, Mazidi SM, Hosseini SH, Geramifar P, Beiki D, Rostampour N, Shahbazi Gahrouei D (2021). Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent. International Journal of Polymeric Materials and Polymeric Biomaterials, 70(15), 1077-1089.
Chicago	Almasi T, Gholipour N, Akhlaghi M, Mokhtari Kheirabadi A, Mazidi SM, Hosseini SH, Geramifar P, Beiki D, Rostampour N, Shahbazi Gahrouei D. "Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent." International Journal of Polymeric Materials and Polymeric Biomaterials 70, no. 15 (2021): 1077-1089.
Harvard	Almasi T et al. (2021) 'Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent', International Journal of Polymeric Materials and Polymeric Biomaterials, 70(15), pp. 1077-1089.
Vancouver	Almasi T, Gholipour N, Akhlaghi M, Mokhtari Kheirabadi A, Mazidi SM, Hosseini SH, et al.. Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent. International Journal of Polymeric Materials and Polymeric Biomaterials. 2021;70(15):1077-1089.
BibTex	@article{ author = {Almasi T and Gholipour N and Akhlaghi M and Mokhtari Kheirabadi A and Mazidi SM and Hosseini SH and Geramifar P and Beiki D and Rostampour N and Shahbazi Gahrouei D}, title = {Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent}, journal = {International Journal of Polymeric Materials and Polymeric Biomaterials}, volume = {70}, number = {15}, pages = {1077-1089}, year = {2021} }
RIS	TY - JOUR AU - Almasi T AU - Gholipour N AU - Akhlaghi M AU - Mokhtari Kheirabadi A AU - Mazidi SM AU - Hosseini SH AU - Geramifar P AU - Beiki D AU - Rostampour N AU - Shahbazi Gahrouei D TI - Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent JO - International Journal of Polymeric Materials and Polymeric Biomaterials VL - 70 IS - 15 SP - 1077 EP - 1089 PY - 2021 ER -

Style

Citing Format

MLA

Almasi T, et al.. "Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent." International Journal of Polymeric Materials and Polymeric Biomaterials, vol. 70, no. 15, 2021, pp. 1077-1089.

APA

Almasi T, Gholipour N, Akhlaghi M, Mokhtari Kheirabadi A, Mazidi SM, Hosseini SH, Geramifar P, Beiki D, Rostampour N, Shahbazi Gahrouei D (2021). Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent. International Journal of Polymeric Materials and Polymeric Biomaterials, 70(15), 1077-1089.

Chicago

Almasi T, Gholipour N, Akhlaghi M, Mokhtari Kheirabadi A, Mazidi SM, Hosseini SH, Geramifar P, Beiki D, Rostampour N, Shahbazi Gahrouei D. "Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent." International Journal of Polymeric Materials and Polymeric Biomaterials 70, no. 15 (2021): 1077-1089.

Harvard

Almasi T et al. (2021) 'Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent', International Journal of Polymeric Materials and Polymeric Biomaterials, 70(15), pp. 1077-1089.

Vancouver

Almasi T, Gholipour N, Akhlaghi M, Mokhtari Kheirabadi A, Mazidi SM, Hosseini SH, et al.. Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent. International Journal of Polymeric Materials and Polymeric Biomaterials. 2021;70(15):1077-1089.

BibTex

@article{ author = {Almasi T and Gholipour N and Akhlaghi M and Mokhtari Kheirabadi A and Mazidi SM and Hosseini SH and Geramifar P and Beiki D and Rostampour N and Shahbazi Gahrouei D}, title = {Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent}, journal = {International Journal of Polymeric Materials and Polymeric Biomaterials}, volume = {70}, number = {15}, pages = {1077-1089}, year = {2021} }

RIS

TY - JOUR
AU - Almasi T
AU - Gholipour N
AU - Akhlaghi M
AU - Mokhtari Kheirabadi A
AU - Mazidi SM
AU - Hosseini SH
AU - Geramifar P
AU - Beiki D
AU - Rostampour N
AU - Shahbazi Gahrouei D
TI - Development of Ga-68 Radiolabeled Dota Functionalized and Acetylated Pamam Dendrimer-Coated Iron Oxide Nanoparticles As Pet/Mr Dual-Modal Imaging Agent
JO - International Journal of Polymeric Materials and Polymeric Biomaterials
VL - 70
IS - 15
SP - 1077
EP - 1089
PY - 2021
ER -

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Abstract