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Possible Role of Cns Micrornas in Human Mpox Virus Encephalitis—A Mini-Review Publisher Pubmed



Soltani S1 ; Shahbahrami R1 ; Jahanabadi S2 ; Siri G3 ; Emadi MS4 ; Zandi M1
Authors
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Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Specialist of Infectious and Tropical Diseases, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  3. 3. Department of Internal Medicine, School of Medicine, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of NeuroVirology Published:2023


Abstract

In May 2022, a re-emerging viral pathogen belonging to the Poxviridae was first reported from the UK, and WHO confirmed the outbreak after the prevalence of the disease increased. As of February 15, 2023, more than 85,000 confirmed cases have been recorded in 110 countries. Due to the spread of the virus across multiple countries, WHO declared the mpox outbreak as a public health emergency. Human mpox virus is an enveloped virus with a linear double-stranded DNA that can cause encephalitis with neurological complications such as pharyngitis, fever, anorexia, adenopathy, vesiculopapular rash, and headache. Dysregulation of microRNAs in viral encephalitis has been reported in a variety of documents. In this mini-review, we aim to discuss the possibility of CNS-related microRNA dysregulation in mpox-related encephalitis. © 2023, The Author(s) under exclusive licence to The Journal of NeuroVirology, Inc.
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