Butanol Fraction of Kelussia Odoratissima Mozaff Inhibits the Growth of Leishmania Major Promastigote and Amastigote

Butanol Fraction of Kelussia Odoratissima Mozaff Inhibits the Growth of Leishmania Major Promastigote and Amastigote Publisher

Mirzaei F^{1, 2} ; Norouzi R³ ; Siyadatpanah A⁴ ; Mitsuwan W⁵ ; Nilforoushzadeh M^{6, 7} ; Maleksabet A⁸ ; Hosseini M⁹ ; De Lourdes Pereira M¹⁰ ; Nissapatorn V⁵ ; Hejazi SH^{2, 7}

Show Affiliations

1. Department of Parasitology and Mycology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2. Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3. Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
4. Ferdows School of Paramedical and Health, Birjand University of medical sciences, Birjand, Iran
5. School of Allied Health Sciences, World Union for Herbal Drug Discovery (WUHeDD), and Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat, Thailand
6. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
7. Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
8. Department of Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
9. Department of Biostatistics and Epidemiology, School of Public Health, IUMS, Isfahan, Iran
10. CICECO-Aveiro Institute of Materials and Department of Medical Sciences, University of Aveiro, Aveiro, Portugal

Source: World's Veterinary Journal Published:2020

Abstract

Naturally derived compounds have been used to treat several infectious diseases including leishmaniasis. The study aimed to investigate the in vitro effects of Kelussia odoratissima Mozaff extract on Leishmania major promastigote and amastigote. Dried leaves of K. odoratissima were fractionated by 3 solvents including aqueous, butanol, and ethyl acetate. The results showed that the butanol fraction of K. odoratissima showed the highest anti-Leishmania effects against L. major promastigotes. Ninety four percent growth inhibition of the promastigote was observed when cells were treated with the 1,280 μg/mL butanol fractions. Moreover, 100% inhibition of amastigotes was detected after treatment with the butanol fraction. Half maximal inhibitory concentration (IC50>) of the butanol fraction in promastigotes and amastigotes was 264.1 and 154.1 μg/mL, respectively. The obtained results suggested the potential medicinal benefits of K. odoratissima butanol fraction as an alternative treatment for leishmaniasis caused by L. major infections. © 2020 Scienceline Publication .

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Style	Citing Format
MLA	Mirzaei F, et al.. "Butanol Fraction of Kelussia Odoratissima Mozaff Inhibits the Growth of Leishmania Major Promastigote and Amastigote." World's Veterinary Journal, vol. 10, no. 2, 2020, pp. 254-259.
APA	Mirzaei F, Norouzi R, Siyadatpanah A, Mitsuwan W, Nilforoushzadeh M, Maleksabet A, Hosseini M, De Lourdes Pereira M, Nissapatorn V, Hejazi SH (2020). Butanol Fraction of Kelussia Odoratissima Mozaff Inhibits the Growth of Leishmania Major Promastigote and Amastigote. World's Veterinary Journal, 10(2), 254-259.
Chicago	Mirzaei F, Norouzi R, Siyadatpanah A, Mitsuwan W, Nilforoushzadeh M, Maleksabet A, Hosseini M, De Lourdes Pereira M, Nissapatorn V, Hejazi SH. "Butanol Fraction of Kelussia Odoratissima Mozaff Inhibits the Growth of Leishmania Major Promastigote and Amastigote." World's Veterinary Journal 10, no. 2 (2020): 254-259.
Harvard	Mirzaei F et al. (2020) 'Butanol Fraction of Kelussia Odoratissima Mozaff Inhibits the Growth of Leishmania Major Promastigote and Amastigote', World's Veterinary Journal, 10(2), pp. 254-259.
Vancouver	Mirzaei F, Norouzi R, Siyadatpanah A, Mitsuwan W, Nilforoushzadeh M, Maleksabet A, et al.. Butanol Fraction of Kelussia Odoratissima Mozaff Inhibits the Growth of Leishmania Major Promastigote and Amastigote. World's Veterinary Journal. 2020;10(2):254-259.
BibTex	@article{ author = {Mirzaei F and Norouzi R and Siyadatpanah A and Mitsuwan W and Nilforoushzadeh M and Maleksabet A and Hosseini M and De Lourdes Pereira M and Nissapatorn V and Hejazi SH}, title = {Butanol Fraction of Kelussia Odoratissima Mozaff Inhibits the Growth of Leishmania Major Promastigote and Amastigote}, journal = {World's Veterinary Journal}, volume = {10}, number = {2}, pages = {254-259}, year = {2020} }
RIS	TY - JOUR AU - Mirzaei F AU - Norouzi R AU - Siyadatpanah A AU - Mitsuwan W AU - Nilforoushzadeh M AU - Maleksabet A AU - Hosseini M AU - De Lourdes Pereira M AU - Nissapatorn V AU - Hejazi SH TI - Butanol Fraction of Kelussia Odoratissima Mozaff Inhibits the Growth of Leishmania Major Promastigote and Amastigote JO - World's Veterinary Journal VL - 10 IS - 2 SP - 254 EP - 259 PY - 2020 ER -

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