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Bioremoval and Biodetoxification of Ciprofloxacin From Hospital Wastewater Effluent by the Efficient and Recyclable Laccase@Hercynite Magnetic Nanoparticles Publisher



Mojtabavi S1 ; Rezayaraghi F1 ; Shahverdi M1 ; Golroudbari HT1 ; Moshiri F1 ; Faramarzi MA1
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  1. 1. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy & Biotechnology Research Center, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, 1417614411, Iran

Source: Journal of Environmental Chemical Engineering Published:2023


Abstract

Fluoroquinolones present in hospital wastewater potentially threaten human health security due to the development of antibiotic-resistant bacteria and genes. Today enzymatic treatments are known as a promising method for the removal of antibiotic residues from environmental waters. In the present study, laccase was adsorbed on the surface of hercynite (FeAl2O4) magnetic nanoparticles (MNPs) to remove ciprofloxacin from hospital wastewater (HWW) with high stability and efficiency. For this purpose, the hercynite MNPs were fabricated via the co-precipitation method, and their surface was subsequently modified by copper (II) ions to create coupling with the functional groups of the enzyme. The catalytic activity of laccase@Cu2+@hercynite•MNPs was preserved up to 50% of its initial activity after 13 cycles of reuse. The stability of the adsorbed enzyme was 2.2-fold and 4-fold higher than the free laccase after one month of storage at 4 °C and 25 °C, respectively. The immobilized laccase removed 85% of ciprofloxacin in HWW after 3 h incubation with 1 mM p-coumaric acid at 40 °C. The removal process involved defluorination, hydroxylation, and piperazine ring cleavage, which reduced the antibiotic toxicity against G+ and G– bacteria. Thus, laccase@Cu2+@hercynite•MNPs can be recommended for the bioremediation of micro-pollutants from hospital effluents. © 2023 Elsevier Ltd
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