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Elimination and Detoxification of Sulfathiazole and Sulfamethoxazole Assisted by Laccase Immobilized on Porous Silica Beads Publisher



Rahmani K1 ; Faramarzi MA2 ; Mahvi AH3 ; Gholami M1 ; Esrafili A1 ; Forootanfar H4 ; Farzadkia M1
Authors
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Authors Affiliations
  1. 1. Department of Environmental Health Engineering, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, 14176, Iran
  3. 3. Department of Environmental Health Engineering, School of Public Health, Center for Solid Waste Research, Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran

Source: International Biodeterioration and Biodegradation Published:2015


Abstract

This study assessed the immobilization of laccase on CPC silica beads and removal of two sulfonamides, sulfathiazole (STZ) and sulfamethoxazole (SMZ), using free and immobilized laccase. The results showed that free laccase (1Uml-1) removed 66% and 77% of SMZ and STZ, respectively, in the presence of 1-hydroxybenzotriazole (1mM) as a laccase mediator after incubation at 40°C for 1h. Maximum enzymatic removal of both applied sulfonamides was achieved at a temperature of 50°C and a pH of 5. At the elevated temperature of 70°C, immobilized laccase removed 71.7% of STZ and 53% of SMZ. After ten cycles of removal experiments, 63.3% and 82.6% of the initial activity of the immobilized laccase toward SMZ and STZ remained, respectively. A lower Km value for STZ (0.056mM) compared to that of SMZ (0.096mM) confirmed a higher affinity of immobilized laccase toward STZ. A microtoxicity study of the inhibition of bacterial growth showed a decrease in toxicity of the laccase-treated sulfonamide solution. © 2014 Elsevier Ltd.
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