Association of Hdac8 Expression With Pathological Findings in Triple Negative and Non-Triple Negative Breast Cancer: Implications for Diagnosis

Association of Hdac8 Expression With Pathological Findings in Triple Negative and Non-Triple Negative Breast Cancer: Implications for Diagnosis Publisher Pubmed

Menbari MN¹ ; Rahimi K^{2, 3} ; Ahmadi A¹ ; Mohammadiyeganeh S^{4, 5} ; Elyasi A⁶ ; Darvishi N¹ ; Hosseini V¹ ; Abdi M^{1, 7}

Show Affiliations

1. Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
2. Department of Molecular Biology and Genetics, Gene Expression and Gene Medicine, Aarhus University, Aarhus, Denmark
3. Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark
4. Medical Nanotechnology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6. Department of Surgery, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
7. Department of Clinical Biochemistry, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

Source: Iranian Biomedical Journal Published:2020

Abstract

Background: Previous data have shown the tumorigenicity roles of HDAC8 in breast cancer. More recently, the oncogenic effects of this molecule have been revealed in TNBC. The present study aimed to determine the diagnostic value of HDAC8 for the differentiation of TNBC from nTNBC tumors. Methods: A total of 50 cancerous and normal adjacent tumor specimens were obtained, and the clinical and pathological findings of studied subjects were recorded. The expression of HDAC8 gene was determined by qRT-PCR. Also, immunohistochemical staining was performed on tissue samples. Results: Our results showed that the expression of HDAC8 in breast cancer tissues was significantly higher than the normal adjacent tissues (p = 0.0011). HDAC8 expression was also observed to be higher in TNBC patients than nTNBC group (p = 0.0013). In addition, in the TNBC group, there was a significant association between the HDAC8 overexpression and tumor characteristics, including tumor size (p = 0.039), lymphatic invasion (p = 0.01), tumor grade (p = 0.02), and perineural invasion (p < 0.05). The cut-off value was fixed at 0.6279 r.u., and the corresponding sensitivity and specificity were found to be 73.91% and 70.37%, respectively. Conclusion: According to the findings, among the other markers, HDAC8 oncogene may be used as a potential tumor marker in diagnosis of TNBC tumors. © 2020, Pasteur Institute of Iran. All rights reserved.

2. Mir-216B-5P Inhibits Cell Proliferation in Human Breast Cancer by Down-Regulating Hdac8 Expression, Life Sciences (2019)

3. Prospect and Competence of Quantitative Methods Via Real-Time Pcr in a Comparative Manner: An Experimental Review of Current Methods, Open Bioinformatics Journal (2018)

Style	Citing Format
MLA	Menbari MN, et al.. "Association of Hdac8 Expression With Pathological Findings in Triple Negative and Non-Triple Negative Breast Cancer: Implications for Diagnosis." Iranian Biomedical Journal, vol. 24, no. 5, 2020, pp. 283-289.
APA	Menbari MN, Rahimi K, Ahmadi A, Mohammadiyeganeh S, Elyasi A, Darvishi N, Hosseini V, Abdi M (2020). Association of Hdac8 Expression With Pathological Findings in Triple Negative and Non-Triple Negative Breast Cancer: Implications for Diagnosis. Iranian Biomedical Journal, 24(5), 283-289.
Chicago	Menbari MN, Rahimi K, Ahmadi A, Mohammadiyeganeh S, Elyasi A, Darvishi N, Hosseini V, Abdi M. "Association of Hdac8 Expression With Pathological Findings in Triple Negative and Non-Triple Negative Breast Cancer: Implications for Diagnosis." Iranian Biomedical Journal 24, no. 5 (2020): 283-289.
Harvard	Menbari MN et al. (2020) 'Association of Hdac8 Expression With Pathological Findings in Triple Negative and Non-Triple Negative Breast Cancer: Implications for Diagnosis', Iranian Biomedical Journal, 24(5), pp. 283-289.
Vancouver	Menbari MN, Rahimi K, Ahmadi A, Mohammadiyeganeh S, Elyasi A, Darvishi N, et al.. Association of Hdac8 Expression With Pathological Findings in Triple Negative and Non-Triple Negative Breast Cancer: Implications for Diagnosis. Iranian Biomedical Journal. 2020;24(5):283-289.
BibTex	@article{ author = {Menbari MN and Rahimi K and Ahmadi A and Mohammadiyeganeh S and Elyasi A and Darvishi N and Hosseini V and Abdi M}, title = {Association of Hdac8 Expression With Pathological Findings in Triple Negative and Non-Triple Negative Breast Cancer: Implications for Diagnosis}, journal = {Iranian Biomedical Journal}, volume = {24}, number = {5}, pages = {283-289}, year = {2020} }
RIS	TY - JOUR AU - Menbari MN AU - Rahimi K AU - Ahmadi A AU - Mohammadiyeganeh S AU - Elyasi A AU - Darvishi N AU - Hosseini V AU - Abdi M TI - Association of Hdac8 Expression With Pathological Findings in Triple Negative and Non-Triple Negative Breast Cancer: Implications for Diagnosis JO - Iranian Biomedical Journal VL - 24 IS - 5 SP - 283 EP - 289 PY - 2020 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract