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The Association Between Vitamin C and Breast Cancer, Prostate Cancer and Colorectal Cancer: A Systematic Review and Meta-Analysis Publisher Pubmed



Arshadi M1 ; Ghazal N2 ; Ghavidel F3 ; Beygi Z4 ; Nasiri Z5 ; Zarepour P3 ; Abdollahi S3 ; Azizi H6 ; Khodamoradi F7
Authors
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Authors Affiliations
  1. 1. Department of Epidemiology and Biostatistics, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  2. 2. Student Research Committee of Shahid Sadougi University of Medical Sciences, Yazd, Iran
  3. 3. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Midwife and Nursing, Maybod Branch, Islamic Azad University, Maybod, Iran
  5. 5. Department of Social Medicine, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Clinical Nutrition ESPEN Published:2025


Abstract

Background: For a comprehensive evaluation and due to the inconsistent results of previous studies, we performed this meta-analysis with the aim of vitamin C effect on breast cancer and prostate cancer and colorectal cancer. Methods: PubMed, Scopus and Web of Science were searched to identify studies on the association between vitamin C and breast cancer, prostate cancer and colorectal cancer through September 11, 2023. The pooled RR and the 95 % confidence intervals were used to measure the association between vitamin C and breast cancer, prostate cancer and colorectal cancer by assuming a random effects meta-analytic model. Newcastle–Ottawa scale was used for quality appraisal. Results: A total of 69 studies were included. The pooled RR for the association between vitamin C (dietary) and breast cancer in the cohort study was 0.99 [95 % CI: 0.95, 1.03], but the pooled RR in the case-control study was 0.72 [95 % CI: 0.60, 0.85]. No association was found between vitamin E (supplemental, total intake) and breast cancer in studies. The pooled RR for the association between vitamin C (dietary) and prostate cancer was 0.88 [95 % CI: 0.77, 1.00], which represents a decrease in prostate cancer. No association was found between vitamin C (supplemental) and prostate cancer in studies. The pooled RR for the association between vitamin C (dietary) and colorectal cancer was 0.55 [95 % CI: 0.42, 0.73], which represents a decrease in colorectal cancer. Conclusion: Our analysis shows an inverse significant relationship between vitamin C (dietary) and breast cancer in the case-control study. Also between vitamin C (dietary) and prostate cancer and colorectal cancer in studies, which represents a decrease in cancers. © 2024 European Society for Clinical Nutrition and Metabolism
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