Structure-Based Drug Design of New Cinnamic Acid Derivatives As Tyrosinase Inhibitors

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Structure-Based Drug Design of New Cinnamic Acid Derivatives As Tyrosinase Inhibitors Publisher

F Yousefnejad FAEZE ; Mh Sayahi Mohammad HOSEIN ; A Moazzam ALI ; F Gholami FATEMEH ; N Tanideh NADER ; C Irajie CAMBYZ ; H Tayebi HELIA ; F Rasekh FATEMEH ; Ba Larijani Bagher A ; Mh Barazandeh Tehrani Maliheh HOSSEINPOUR

Source: Letters in Organic Chemistry Published:2024

Abstract

Tyrosinase is a critical enzyme responsible for pigmentation disorders, and tyrosinase inhibition is an established strategy to treat hyperpigmentation. In the current study, cinnamic acid-based derivatives were designed and synthesized. All synthesized compounds were confirmed using IR, 1HNMR, 13CNMR, and CNH analysis. The inhibitory potencies of all derivatives against tyrosinase were determined, and it was shown that 5m bearing parachloro moiety exhibits an IC50 value of 77.62 μmol/L. Analysis of enzyme kinetic studies revealed that 5m is an uncompetitive inhibitor. In silico studies against tyrosinase predicted possible binding mode in the pocket such that 5m formed critical interactions with both Cu co-factors within the binding site. This study presents the potential of aryl-substituted cinnamic acids that can benefit various cosmetic formulations as depigmentation agents. © 2024 Elsevier B.V., All rights reserved.

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Style	Citing Format
MLA	F Yousefnejad FAEZE, et al.. "Structure-Based Drug Design of New Cinnamic Acid Derivatives As Tyrosinase Inhibitors." Letters in Organic Chemistry, vol. 21, no. 8, 2024, pp. 647-654.
APA	F Yousefnejad FAEZE, Mh Sayahi Mohammad HOSEIN, A Moazzam ALI, F Gholami FATEMEH, N Tanideh NADER, C Irajie CAMBYZ, H Tayebi HELIA, F Rasekh FATEMEH, Ba Larijani Bagher A, Mh Barazandeh Tehrani Maliheh HOSSEINPOUR (2024). Structure-Based Drug Design of New Cinnamic Acid Derivatives As Tyrosinase Inhibitors. Letters in Organic Chemistry, 21(8), 647-654.
Chicago	F Yousefnejad FAEZE, Mh Sayahi Mohammad HOSEIN, A Moazzam ALI, F Gholami FATEMEH, N Tanideh NADER, C Irajie CAMBYZ, H Tayebi HELIA, F Rasekh FATEMEH, Ba Larijani Bagher A, Mh Barazandeh Tehrani Maliheh HOSSEINPOUR. "Structure-Based Drug Design of New Cinnamic Acid Derivatives As Tyrosinase Inhibitors." Letters in Organic Chemistry 21, no. 8 (2024): 647-654.
Harvard	F Yousefnejad FAEZE et al. (2024) 'Structure-Based Drug Design of New Cinnamic Acid Derivatives As Tyrosinase Inhibitors', Letters in Organic Chemistry, 21(8), pp. 647-654.
Vancouver	F Yousefnejad FAEZE, Mh Sayahi Mohammad HOSEIN, A Moazzam ALI, F Gholami FATEMEH, N Tanideh NADER, C Irajie CAMBYZ, et al.. Structure-Based Drug Design of New Cinnamic Acid Derivatives As Tyrosinase Inhibitors. Letters in Organic Chemistry. 2024;21(8):647-654.
BibTex	@article{ author = {F Yousefnejad FAEZE and Mh Sayahi Mohammad HOSEIN and A Moazzam ALI and F Gholami FATEMEH and N Tanideh NADER and C Irajie CAMBYZ and H Tayebi HELIA and F Rasekh FATEMEH and Ba Larijani Bagher A and Mh Barazandeh Tehrani Maliheh HOSSEINPOUR}, title = {Structure-Based Drug Design of New Cinnamic Acid Derivatives As Tyrosinase Inhibitors}, journal = {Letters in Organic Chemistry}, volume = {21}, number = {8}, pages = {647-654}, year = {2024} }
RIS	TY - JOUR AU - F Yousefnejad FAEZE AU - Mh Sayahi Mohammad HOSEIN AU - A Moazzam ALI AU - F Gholami FATEMEH AU - N Tanideh NADER AU - C Irajie CAMBYZ AU - H Tayebi HELIA AU - F Rasekh FATEMEH AU - Ba Larijani Bagher A AU - Mh Barazandeh Tehrani Maliheh HOSSEINPOUR TI - Structure-Based Drug Design of New Cinnamic Acid Derivatives As Tyrosinase Inhibitors JO - Letters in Organic Chemistry VL - 21 IS - 8 SP - 647 EP - 654 PY - 2024 ER -

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