Predictors of Aneurysmal Occlusion Following Intracranial Aneurysms Treatment With Pipeline Embolization Device Publisher Pubmed



Salem MM¹ ; Khorasanizadeh MH¹ ; Nwajei F¹ ; Gomezpaz S¹ ; Akamatsu Y¹ ; Jordan N¹ ; Maroufi SF² ; Thomas AJ³ ; Ogilvy CS¹ ; Moore JM¹
Source: Acta Neurochirurgica Published:2023

Abstract

Purpose: Pipeline embolization device (PED) is thought to induce aneurysmal occlusion through diversion of flow away from the aneurysmal sac with subsequent thrombosis and endothelialization. The impact of different factors especially hypertension (HTN)—a known predisposing factor to hypercoagulability and altered endothelial function—on aneurysmal occlusion after flow diversion has not been studied. We sought to determine predictors of aneurysmal occlusion following PED treatment focusing on impact of blood pressure. Methods: Database of patients with cerebral aneurysms treated with PED from 2013 to 2019 at our institution was retrospectively reviewed. Patients were defined as hypertensive if (1) they had a documented history of HTN requiring anti-HTN medications or (2) average systolic blood pressure on three measurements was > 130 mmHg. The primary outcome was aneurysm occlusion status at the last imaging follow-up. Multivariable logistic regression model was constructed to assess the effect of HTN on occlusion, controlling for age, smoking, aneurysmal size, fusiform morphology, posterior circulation location, and incorporated branches. Results: A total of 331 aneurysms in 294 patients were identified for this analysis. The mean age was 59 years (79.9% female). Fifty-five percent of the cohort were classified as hypertensive. When controlling for other potential confounders, hypertensive patients trended toward higher odds of achieving complete occlusion compared to non-hypertensive patients (OR = 2.05; 95% CI = 0.99–4.25; p = 0.052). Meanwhile, age (OR = 0.91; 95% CI = 0.88–0.95; p < 0.001) and an incorporated branch into an aneurysm (OR = 0.22; 95% CI = 0.08–0.58; p < 0.002) were associated with decreased odds for complete aneurysmal occlusion. Conclusion: Hypertensive patients show a trend toward higher odds of achieving complete occlusion when controlling for potential confounders. The HTN-induced hypercoagulable state, enhanced endothelial activation, and altered extracellular matrix regulation might be the contributing factors. Further research is warranted to explore clinical implications of these findings. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.