Therapeutic Effect of Resveratrol and Its Novel Formulations on Lung Cancer: Focus on Biological Aspects and Underlying Pathways Publisher Pubmed



H Poortalebi HAMIDREZA ; M Zaredini MAHTA ; S Foroughinematollahi SIMA ; T Farkhondeh T ; S Samarghandian SAEED ; Mh Pourhanifeh Mohammad HOSSEIN
Source: Current Medicinal Chemistry Published:2024

Abstract

Lung cancer is a leading cause of mortality and morbidity worldwide. Due to significant advances in therapeutic strategies, patients' survival and life quality have been improved, however there is still an urgent requirement for developing more effec-tive therapeutic methods. Resveratrol, a natural polyphenol with numerous biological po-tentials, has been widely studied. It has shown therapeutic potetial in various diseases in-cluding neurodegenerative diseases, cardiovascular disorders, and cancers through the regulation of key cellular signaling such as apoptosis, as well as molecular pathways such as microRNA modulation. It has been reported that resveratrol acts as an anticancer agent against lung cancer in vivo and in vitro. Resveratrol could combat against lung cancer by modulating various molecular targets and signaling pathways involved in oxidative stress, inflammation, apoptosis and autoghagy and also microRNAs expres-sion. Moreover, novel delivery systems and analogs have recently been introduced to promote the anticancer impacts of resveratrol. In this article, we review current evidence on the anticancer effects of resveratrol and its novel formulations in the treatment of lung cancer with a focus on underlying mechanisms. © 2024 Elsevier B.V., All rights reserved.